目的 探讨IPS e.max Press铸瓷全冠修复对牙周组织的影响。方法 选择IPS e.max Press铸瓷全冠修复患者79例107颗患牙，在修复前和修复后6个月，测定龈沟液(gingival crevicular fluid，GCF)量，并采用酶联免疫吸附试验(ELISA)分别对龈沟液中干扰素-γ(IFN-γ)、肿瘤坏死因子(TNF- α)、基质金属蛋白酶-2(MMP-2)水平进行分析。结果 修复后 GCF量、IFN-γ、TNF- α、MMP-2水平与修复前比较差异无统计学意义(P＞0.05)。结论 IPS e.max Press铸瓷全冠对牙周组织无明显影响，是一种生物相容性良好的修复方式。

Objective To observe the effects of IPS e.max Press ceramic crown on the periodontal tissue of the prosthetic teeth. Methods 79 clinical patients(107 anterior teeth)were selected to receive prosthesis with IPS e.max press ceramic crown ,and before and 6 months after prothesis,the weight of gingival crevicular fluid (GCF) was measured and the level of interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α) and matrix metalloproteinase-2 (MMP-2) in GCF was checked by enzyme-linked immunosorbent assay,and the result was analyzed. Results The weight of GCF,the level of IFN－γ,TNF-α,MMP-2 in GCF after prosthesis had no statistically significant difference with those before prosthesis (P＞0.05). Conclusions IPS e.max press ceramic crown has no significant negative influence on gingival health of the restored teeth. And it is a kind of restoration with favorable biocompatibility.