目的 观察白藜芦醇对重症急性胰腺炎(severe acute pancreatitis，SAP)大鼠血清炎性细胞因子的影响。方法 取SD大鼠，经胆胰管逆行注射5%牛磺胆酸钠制备SAP模型，分为假手术组、模型组、白藜芦醇组(20、10、5 mg/kg)，每组16只。采用尾静脉注射给药，术后6 h和12 h分别于光镜下观察胰腺组织的病理学改变，ELISA法检测血清肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)和IL-6水平。结果 白藜芦醇各剂量均能减轻胰腺组织的炎性反应，病理评分与模型组比较，明显降低(P＜0.01);术后6 h各剂量对应TNF-α[(89.0±19.2)、(84.7±16.0)、(105.6±22.3)ng/L]、IL-1[(109.3±19.8)、(114.5±30.2)、(135.5±29.2) ng/L]和IL-6 [(185.3±28.8)、(201.5±44.0)、(213.0±30.7)ng/L]，水平均明显低于模型组(P＜0.05或P＜0.01)。术后12 h情况同术后6 h。结论 白藜芦醇通过减少炎性细胞因子的过度释放，对大鼠SAP具有保护作用。

Objective To investigate the effects of resveratrol (Res) on expression of serum inflammatory cytokines in rats with severe acute pancreatitis (SAP). Methods SAP model was induced by intraductal administration of 5% taurocholic acid sodium salt. SD rats were then randomly divided into 3 groups (n=16), namely normal, model and Res group (5, 10 and 20 mg/kg). Drugs were administered via caudal vein 30 min post-operation. The levels of TNF-α, IL-1 and IL-6 in serum were measured by ELISA, and pancreatic histological changes were observed under microscope 6 h and 12 h post-operation. Resluts Res veratrol evidently reduced the severity of pancreatic pathology in rats with SAP, compared with model group (P<0.01). Res veratrol significantly inhibited the levels of TNF-α [(89.0±19.2), (84.7±16.0)and (105.6±22.3) ng/L, respectively], IL-1 [(109.3±19.8), (114.5±30.2) and (135.5±29.2) ng/L, respectively] and [IL-6 (185.3±28.8), (201.5±44.0) and (213.0±30.7) ng/L, respectively] in serum 6 h post-operation (P<0.05 or P<0.01), and those of TNF-α, IL-1 and IL-6 12 h post-operation (P<0.01). Conclusions Res veratrol can inhibit the expression of inflammatory cytokines, and protect rats with SAP effectively.