目的 了解抽动-秽语综合征(tourette’s syndrome，TS)患儿尿单氨类神经递质代谢产物香草扁桃酸(vanillylmandelic acid，VMA)水平，探讨其与疾病发生的意义。方法 以40例TS患儿为病例组，33例健康儿童作为正常对照组。采集研究对象的尿液，经高效液相色谱法分离后利用库仑阵列电化学检测香草扁桃酸(VMA)水平，紫外检测器检测作为校正因素的肌酐含量。利用VMA/Cr代表尿样中VMA的水平。结果 病例组尿液VMA/Cr值为:(1.597±0.095)μg/mg ，对照组VMA/Cr值为(2.198±0.112)μg/mg ，病例组尿液VMA/Cr均值显著低于对照组(P＜0.001) ，病例组和对照组VMA/Cr均值男女之间差异均无统计学意义。结论 TS患儿中存在VMA水平异常 。

Objective To study the levels of urinary vanillylmandelic acid (VMA) metabolite in children with Tourette ’s syndrome (TS) and its relationship with disease significance. Methods VMA levels in fresh urine of 40 Childrem with TS as study group and in 33 healthy children’s urine as normal controls were measured by high performance liquid chromatography coulometric electrochemical array, and urine creatinine (Cr) was used for correction. Results VMA/Cr value in urine of study group was (1.597±0.095)μg/mg, and VMA/Cr value in control group was (2.198±0.112) μg/mg. Value of VMA/Cr in urine of study group was significantly lower than that the control group(P<0.001) and mean values of VMA/Cr were not significantly different in the study group and control group between men and women. Conclusion VMA level is abnormal in with Tourette’s syndrome children.