目的 观察中枢神经细胞瘤(central neurocytoma， CNC)的影像学表现、临床病理特征与免疫组化特点，探讨其治疗方法及预后。方法 回顾性分析15例CNC患者的临床表现，CT、MRI扫描观察其影像学特征，HE及免疫组化染色观察其病理及免疫表型特点，患者随访评估预后。结果 肿瘤大多位于侧脑室邻近Monro孔，CT扫描呈等或稍高不均匀密度影;MRI检查T₁WI上呈等或低信号，T₂WI呈高信号，肿瘤内部可见“蜂窝”状或“丝瓜瓢”样改变。增强扫描呈不均匀斑片状、条状强化。病理所见CNC由圆形或卵圆形细胞组成，有核周空晕，瘤细胞呈蜂窝状结构。免疫组化示肿瘤组织Syn均阳性，CgA均阴性。CNC首选手术切除。15例随访病例中，全切、全切+放疗组未见复发。结论 CNC好发于侧脑室邻近Monro孔处。MRI特征性改变为“丝瓜瓢”状或匍行性流空信号影。Syn阳性表达是可靠的诊断标志。CNC总体预后良好。

Objective To investigate the imaging clinicopathological and immunohistochemical features of central neurocytoma (CNC) and study method of treatment and prognosis of CNC. Methods The clinical presentation of 15 CNC patients were analysed retrospectively. Imaging features were explored by CT and MRI scans. The pathological and immunophenotypic characteristics were observed by HE and immunohistochemical staining. Treatment effects and prognosis were followed up in the patients. Results CNC were located in lateral ventricle near the Monro foramen and exhibited to be isodense or hyperdense on CT scan. On T1-weighted MRI images, CNC were isointense or hypointense. On T2-weighted images, they were hyperintense. Honeycomb or towel gourd ladle changes can be seen in the tumor. Patched and stripped enhancemens were found after gadolinium administration. CNC were constituted of round or oval monomorphic cells with perinuclear halos. Intracellular branching capillaries formed the characteristic honeycomb structure of CNC. Positive expression of Syn and negative CgA were found in all tumor tissures by immunohistochemical staining method. Surgical resection was the primary therapy of CNC. In the 15 patients followed-up, no recurrence were seen in the total resection and total resection with radiotherapy groups. Conclusions CNC is located mainly in lateral ventricle near the Monro foramen. Positive expression of Syn can be viewed as the reliable diagnostic criteron. Towel gourd ladle or serpiginus flow voids are characteristic MRI changes of CNC. The tumor should be removed totally and CNC has a benign prognosis in general.