目的 探讨小剂量磷酸肌酸钠联合甲状腺素对甲状腺功能减退性心脏病患者的短期临床疗效。方法 将26例甲状腺功能减退性心脏病患者随机分为观察组13例，对照组13例。对照组常规口服甲状腺素30 d，观察组在此基础上加用小剂量磷酸肌酸钠10 d。超声心动图测量两组治疗前后心率（HR)、左室舒张末期内径（LVDd)、左室射血分数(LVEF)、每搏输出量(SV)变化，检验治疗前后患者血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)和乳酸脱氢酶(LDH)水平。结果 治疗30 d后，两组心肌酶CK、CK-MB、LDH较治疗前均明显下降（P＜0.05)；观察组CK、CK-MB、LDH明显低于对照组，差异有统计学意义（P＜0.05或P＜0.01)；两组心率治疗前后及组间比较均无统计学差异；观察组SV、LVEF、LVDd治疗后较治疗前提高（P＜0.05)，对照组治疗前后比较无统计学差异。结论 甲状腺功能减退性心脏病患者短期使用小剂量磷酸肌酸钠联合甲状腺素可以降低患者血清心肌酶水平。

Objective To study the short-term clinical efficacy of levothyroxine combined with low-dose creatine phosphate in heart disease patients with hypothyroidism. Methods Twenty-six patients were divided into two groups randomly:control group of (n=12) was given levothyroxine for 30 days; observation group (n=13) was given levothyroxine for 30 days combined with low-dose creatine phosphate for 10 days. Before and after 30 days’ treatment,left ventricular end diastolic diameter(LVDd),left ventricular ejection fraction(LVEF),stroke volume(SV) measured by echocardiography were observed.Blood samples were collected to measure the plasma concentrations of creatine kinase(CK),creatine kinase-MB(CK-MB) and lactate dehydrogenase(LDH). Results After 30 days treatment, CK,CK-MB,LDH were significantly decreased in the both groups(P＜0.05),but no difference was found in HR.There were significant differences in CK,CK-MB,LDH between the two groups（P＜0.05 or P＜0.01).In the observation group,there were significant differences in SV,LVEF,LVDd (P＜0.05) after treatment,whereas no difference in the control group and between the two groups. Conclutions Levothyroxine combined with short-term low-dose creatine phosphate may lower myocardial enzymes in serum in heart disease patients with hypothyroidism.