目的 探讨玻璃酸钠滴眼液联合重组人表皮生长因子(rhEGF)滴眼液治疗准分子激光原位角膜磨镶术（laser in situ keratomileusis，LASIK）术后干眼症的临床疗效。方法 自2010-3至2012-6选择LASIK术后1年内并确诊为干眼症的患者57例114眼，随机分为治疗组和对照组，治疗组29例58眼采用玻璃酸钠滴眼液联合rhEGF滴眼液滴眼，对照组28例56眼单独使用玻璃酸钠滴眼液。记录患者用药前和用药后2周、4周的干眼自觉症状评分，裂隙灯下观察泪膜破裂时间(BUT)、泪液分泌试验( SIt)、荧光素染色(FL)情况。结果 治疗前两组年龄、性别、干眼症状评分、BUT、SIt、FL差异无统计学意义，用药后各观察时间点治疗组干眼症状评分、BUT，SIt，FL与对照组比较，差异均有统计学意义（P＜0.01）。结论 玻璃酸钠滴眼液联合rhEGF滴眼液治疗LASIK术后干眼症疗效显著优于单独使用玻璃酸钠滴眼液。
Abstract
Objective To evaluate the effects of hyaluronic acid sodium eye drops combined with recombined human epidermal growth factor (rhEGF) eye drops on dry eye after laser in situ keratomileusis. Methods All 57 cases (114 eyes) with dry eye symptom after laser in situ keratomileusis within 1 year were recruited and randomly divided into two groups, the trial group and thecontrol group. In the trial group, the patients were treated with hyaluronic acid sodium eye drops and rhEGF eye drops. In the control group, the patients were treated with only hyaluronic acid sodium eye drops. The subjective dry eye symptoms, fluorescein staining (FL), Schirmer I test （SIt) and tear breakup time (BUT) were observed under the slit lamp before treatment, the second week, and the fourth week after treatment. Results There was no statistically significant difference between the two groups before treatment (P>0.05). After treatment, the subjective dry eye symptoms, FL, SIt and BUT were significantly different (P＜0.01). Conclusions Combined use of hyaluronic acid sodium and rhEGF can show better therapeutic effects than the single use of the eye drops on the dry eye symptom after LASIK.
关键词
玻璃酸钠 /
重组人表皮生长因子 /
准分子激光原位角膜磨镶术 /
干眼症
Key words
hyaluronic acid sodium /
recombined human epidermal growth factor /
laser in situ keratomileusis /
dry eye
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参考文献
［1］ 黄 蒂, 兰雅维, 李 洁，等.武警某部战士干眼患病情况调查［J］. 武警医学, 2011, 22(2):123-126.
［2］ 刘祖国. 眼表疾病学［M］. 北京：人民卫生出版社, 2003:289-290.
［3］ 陈海娥, 赵邯英, 赵玉霞. 准分子激光原位角膜磨镶术后干眼的调查研究［J］. 眼外伤职业眼病杂志, 2006(4):248-251.
［4］ Donnenfeld E D, Solomon K, Perry H D, et al. The effect of hinge position on corneal sensation and dry eye after LASIK［J］. Ophthalmology, 2003, 110(5):1023-1029.
［5］ Toda I, Asano K, Kato N, et al. Dry eye after laser in situ keratomileusis ［J］. Am J Ophthalmol, 2001, 132 (1): 1-7.
［6］ 牛广增, 范玉香, 陈海婷. LASIK术后角膜损伤修复过程中干眼症的影响因素及防治［J］.眼科新进展, 2012,32(6):591-594.
［7］ 廉井财, 朱敏琪, 张 雷. LASIK手术前后干眼症状和泪膜稳定性的研究［J］. 眼科研究,2007,25(2)：127-129.
［8］ 赵江浩, 吴年浪. 玻璃酸钠滴眼液对轻中度干眼病患者角膜表面规则性的影响［J］. 海峡药学,2009,21(11):111-113.
［9］ Wilson S E, Schultz G S, Chegini N, et al. Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, basic growth factor and interleukin-1 proteins in the cornea ［J］. Exp Eye Res, 1994, 59, 63-70.
［10］ Lemp M A. New strategies in the treatment of dry-eye states ［J］. Cornea, 1999, 18:625-632.
［11］ 晁明伦, 王红民. 重组人表皮生长因子在翼状胬肉术后的应用［J］. 眼外伤职业眼病志,2005, 27(2):142-143.
［12］ 张丽娜, 张丽茹, 白艳婷. 易贝滴眼液［J］. 中国新药杂志,2003, 12(2):145.
［13］ 曾志成, 尹海红, 彭清华. 人工泪液联合重组人表皮生长因子滴眼液对白内障囊外摘除术后干眼疗效观察［J］. 国际眼科杂志,2010,10(11):2083-2085.
［14］ 刘祖国, 谢玉环, 张 梅，等. 干眼病患者角膜表面规则性及人工泪液对角膜表面规则性的影响［J］. 中华眼科杂志, 2000, 36 (2): 131-134.
(2012-10-12
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