目的 评估角膜厚度和角膜内皮细胞形态与糖尿病病程的关系。方法 对糖尿病患者120例和健康对照组60例进行中央角膜厚度测量和非接触性角膜内皮检查，用协方差分析法去掉年龄因素的影响后，比较两组中央角膜厚度、内皮细胞密度等。用偏相关系数控制年龄因素之后，检测中央角膜厚度与糖尿病病程的关系。结果 （1）与健康对照组相比，糖尿病组中央角膜厚度增加，内皮细胞密度和六边形细胞百分比降低，且内皮细胞大小不等（P<0.05)；（2）糖尿病病程≥10年组与＜10年组比较，中央角膜厚度和细胞大小变异系数明显升高（P<0.05），角膜内皮细胞密度和六边形细胞百分比降低，但无统计学差异（P>0.05)。结论 在控制年龄因素的影响后，中央角膜厚度与罹患糖尿病的病程长短呈明显相关性，而角膜内皮细胞形态学改变则与糖尿病病程长短无明显的相关性。
Abstract
Objective To assess the change of central corneal thickness (CCT) and corneal endothelium morphology in diabetes mellitus compared with age-matched, healthy control subjects and to test their correlation according to the duration of diabetes. Methods Ultrasound tachymetry and noncontact specular microscopy were performed on 120 patients with diabetes diagnosed by endocrinologists and on 60 control subjects. We compared the values for diabetics and normal persons with ANACOVA to adjust for age. Moreover, we also evaluated the correlation between corneal factors in diabetes and the duration of diabetes using a partial correlation coefficient controlled for age. Results The diabetic subjects had thicker corneas, less cell density and percentage of hexagonal cells,and more irregular cell size of the corneal endothelium than did the controls (P<0.05). Central corneal thickness and the coefficient of variation for cell size significantly increased for diabetes of over 10 years’ duration compared with diabetes of under 10 years’ duration (P<0.05). The endothelial cell density and percentage of hexagonal cells were lower for diabetes of over 10 years’ duration than for diabetes of under 10 years’duration, but not significantly different (P>0.05). Conclusions The central corneal thickness is significantly correlated with the duration of diabetic mellitus after controlling for age.
关键词
糖尿病 /
内皮细胞 /
角膜厚度
Key words
diabetes mellitus /
endothelium /
corneal thickness
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参考文献
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(2012-07-02
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