目的 优选冬凌草甲素脂质体的较优制备工艺。方法 以胆固醇、大豆磷脂为载体, 采用乙醇注入法制备冬凌草甲素脂质体。采用包封率作为为评价指标, 以正交实验设计选出制备脂质体的最佳处方。结果 通过正交设计优选出冬凌草甲素脂质体的制备工艺条件为：冬凌草甲素∶卵磷脂为1∶20, 胆固醇与卵磷脂质量比为5∶1, 超声时间为20 min, 温度为50 ℃。结论 该制备工艺得到的脂质体包封率较高, 形态较好, 方法可行。

Objective To optimize the preparation method of oridonin liposomes. Methods The liposomes were prepared by the ethanol injection method with cholesterin and soybean lecithin as carriers. The envelope efficiency of oridonin liposomes was taken as the observation index to optimize the preparation by orthogonal design. Results Oridonin:phospholipid was 1∶20, cholesterol: phosphatidylcholine was 5∶1, sonication time was 20 min, and temperature was 50 ℃. Conclusions The method is suitable for producing liposome using oridonin, and its form is integrated.