目的 探讨吸烟及戒烟对健康男性动脉僵硬度的影响。方法 将47例具有长期吸烟史的健康男性分为继续吸烟组(26例)和戒烟组(21例);另选28例无吸烟史健康男性作为不吸烟组。采用脉搏波速度自动测量系统测定基线时和1个月、6个月时臂踝脉搏波速度(brachial–ankle pulse wave velocity,baPWV),用于评估动脉僵硬度。结果 基线时继续吸烟组和戒烟组较不吸烟组baPWV值升高(P<0.05)。1个月时戒烟组较继续吸烟组baPWV值差异无统计学意义(15.1 m/s vs 15.2 m/s,P>0.05),戒烟前后差异亦无统计学意义(P>0.05)。6个月时戒烟组较继续吸烟组baPWV值下降(14.2 m/s vs 15.3 m/s,P<0.05),且戒烟后baPWV值较戒烟前也下降(P<0.05)。结论 吸烟可以降低健康男性动脉弹性,戒烟1个月后动脉弹性无改善,但戒烟6个月后动脉弹性可出现改善。
Abstract
Objective To study the effects of smoking and smoking cessation on arterial hardness in healthy subjects. Methods Seventy-five chronic smoking healthy subjects were divided into maintaining smoking group (n=26) and ex-smoking group (n=21).Another 28 no-smoking healthy subjects were used as control group. The arterial hardness reflected by baPWV(brachial-ankle pulse wave velocity) was compared at baseline and after 1 month or 6 months of smoking cessation. Results The maintaining smoking group and ex-smoking group had higher values of baPWV than no-smoking group at baseline(P<0.05). After 1 month of smoking cessation, there was no difference in baPWV between maintaining smoking group and ex-smoking group(P>0.05), the same as between pre- and post-smoking cessation(P>0.05). After 6 month of smoking cessation, there was a decline in baPWV in ex-smoking group, when compared with maintaining smoking group(P<0.05). The same decrease was also observed between pre- and post-smoking cessation(P<0.05). Conclusions Smoking is associated with a decline of the arterial compliance, and 1 month of smoking cessation does not improve the arterial elasticity. But 6 months of smoking cessation improves the arterial elasticity.
关键词
吸烟 /
戒烟 /
臂踝脉搏波速度 /
动脉僵硬度
Key words
smoking /
smoking cessation /
brachial-ankle pulse wave velocity /
arterial hardness
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参考文献
[1] Cao X, Xiao H, Zhang Y, et al. 1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes[J]. Brain Res, 2010,1347:142-148.
[2] Kim J W, Park C G, Hong S J, et al. Acute and chronic effects of cigarette smoking on arterial stiffness[J]. Blood pressure, 2005,14(2):80-85.
[3] Kubozono T, Miyata M, Ueyama K, et al. Acute and chronic effects of smoking on arterial stiffness[J]. Circulation journal : official journal of the Japanese Circulation Society, 2011,75(3):698-702.
[4] O’Rourke M F, Hashimoto J. Mechanical factors in arterial aging: a clinical perspective[J]. Journal of the American College of Cardiology, 2007,50(1):1-13.
[5] Willum-Hansen T, Staessen J A, Torp-Pedersen C, et al. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population[J]. Circulation,2006,113(5):664-670.
[6] 茶春喜,罗 仁,杜晓强, 等. 踝臂脉搏波传导速度对冠状动脉病变的预测价值[J]. 临床和实验医学杂志, 2011,10(10):774-775.
[7] Jatoi N A, Jerrard-Dunne P, Feely J, et al. Impact of smoking and smoking cessation on arterial stiffness and aortic wave reflection in hypertension[J]. Hypertension,2007,49(5):981-985.
[8] Polonia J, Barbosa L, Silva J A, et al. Improvement of aortic reflection wave responses 6 months after stopping smoking: a prospective study[J]. Blood pressure monitoring,2009,14(2):69-75.
