Panayiotopoulos综合征,又称伴有枕叶放电的早发性儿童良性癫,1973年Panayiotopoulos首先对该病进行了报道。这是一种少见的儿童期年龄相关性良性癫,自主神经受累为发作的主要症状,1/5患儿有发作性晕厥。发作初期多数患儿的意识和言语功能保留,但随着发作的进展出现意识和语言障碍,患儿表现为完全无反应状态,肌张力丧失如同布娃娃样。近半数的患儿发作持续时间大于0.5h,也可多达数小时,甚至形成自主神经癫的持续状态。癫发作主要在睡眠中发生,间歇期脑电图常可见多灶性棘波,多数情况下以后头部为主。脑电图发作期放电可从后头部开始,少数情况下从前头部开始[1]。
关键词
Panayiotopoulos综合征 /
鉴别诊断
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Panayiotopoulos C P. Autonomic seizures and autonomic status epilepticus specific to childhood[J].Arch Pediatr Adolesc Med,2002,156 (9): 945.
[2] Nicola Specchio, Marina Trivisano, Vincenzo Di Ciommo, et al. Panayiotopoulos syndrome:A clinical, EEG, and neuropschological study of 93 consective patients[J]. Epilepsia, 2010,51 (10): 2098-2107.
[3] Flesler S, Sakr D, Cersósimo R, et al. Benign infantile focal epilepsy with midline spikes and waves during sleep: a new epileptic syndrome or a variant of benign focal epilepsy? [J].Epileptic Disord,2010,12(3):205-211.
[4] Athanaslos Covanis. Panayiotopoulos syndrome : A benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritis[J].Pediatrics, 2006,18(4):e1237-e1243.
[5] Asano E, Akiyama T. What is the point of specifying Panayiotopoulos syndrome from a practical point of view[J]? Brain Dev,2010,32(1): 2-3.
[6] Yal in A D, Toydemir H E, Celebi L G, et al. Panayiotopoulos syndrome with coincidental brain lesions[J]. Epileptic Disord,2009,11(3):270-276.
[7] Caraballo R H, Aldao Mdel R, Cachia P. Benign childhood seizure susceptibility syndrome: three case reports[J]. Epileptic Disord,2011,13(2):133-139.
[8] Kaul B, Shukla G, Goyal V, et al. Paroxysmal occipital discharges suppressed by eye opening: spectrum of clinical and imaging features at a tertiary care center in India[J]. Neurol India,2012,60(5):461-464.
[9] Schmidt G, Zaiwalla Z, Alexopoulou D, et al. Video-EEG documented lengthy seizure in Panayiotopoulos syndrome: clinical manifestations may be inconspicuous[J]. Epileptic Disord,2012,14(4):426-431.
[10] Díaz-Negrillo A. Panayiotopoulos syndrome and continuous spike-wave during slow sleep[J]. Arq Neuropsiquiatr,2012,70(6):475.
[11] Bolukbasi F, Hamamcioglu I, Demirbilek V, et al. A case imitating Panayiotopoulos syndrome[J]. Epileptic Disord,2011,13(3):304-307.
[12] Martinovic Z. Panayiotopoulos syndrome or early-onset benign childhood occipital epilepsy[J].Epilepsia,2002,43(10):1270-1271.
[13] Ferrie C D, Livingston J H. Panayiotopoulos syndrome: learning lessons from atypical cases[J]. Epileptic Disord,2010,12(1):92-94.
[14] Appleton R E, Tedman B, Preston T, et al. Panayiotopoulos syndrome: a debate[J]. Epileptic Disord,2010,12(1):91.
[15] Colin Ferrie, Roberto Caraballo, Athanasios Covanis, et al. Panayiotopoulos syndrome:a consective view[J]. Developmental Medicine & Child Neurology, 2006, 48: 236-240.
PDF(1048 KB)
