目的探讨血清脂蛋白(a)(lipoproteins,Lpa)水平的变化在冠心病和脑梗死发病中的作用,为心脑血管病的防治提供依据。方法应用胶乳凝集比浊法,分别检测冠心病和脑梗死患者Lp(a)血清水平,同时对其高危人群高血压病和糖尿病患者进行了检测,并以查体正常者作为对照。结果(1)与对照组相比,冠心病和脑梗死患者,以及高血压病、糖尿病患者组的Lp(a)异常比例均明显升高(P<0.05);各组患者的Lp(a)血清水平均也明显升高,其中冠心病、脑梗死和糖尿病组显著升高,有统计学意义(P<0.05);(2)按照年龄分组,冠心病组60岁及以上患者血清Lp(a)水平显著高于60岁以下患者(P<0.05)。其余各组均无显著差异。结论Lp(a)水平与冠心病和脑梗死的发生密切相关,Lp(a)可能是心脑血管病发病的独立危险因素。

Objective To investigate the changes of serum lipoprotein(a)(Lpa) in patients with coronary heart disease and cerebral infarction, and to provide a basis for the prevention and treatment of cardiovascular and cerebrovascular diseases. Methods The Lp(a) was detected by latex agglutination turbidimetry in coronary heart disease patients and cerebral infarction patients,and the hypertension and diabetes patients of their high-risk groups were also observed. Healthy persons served as control group. Results (1)Compared with control group, Lp(a) abnormal proportions were significantly higher in coronary heart disease and cerebral infarction patients groups, also in the hypertension and diabetes patient groups(P<0.05).In the patient groups, Lp(a) serum levels were also obviously elevated, but only in coronary heart disease,cerebral infarction and diabetes patients were statistically significantly higher (P<0.05). (2)For age group, only in coronary heart disease group, Lp(a) serum level was significantly higher in patients ≥60 age than that in patients <60 age (P<0.05). Conclusions Lipoprotein(a) levels are closely related to the occurrence of coronary heart disease and cerebral infarction. The lipoprotein(a) may be an independent risk factor for cardiovascular and cerebrovascular diseases development.