目的探讨慢性阻塞性肺疾病(chronicobstructivepulmonarydisease,COPD)患者T淋巴细胞亚群的特点和细胞因子的变化,了解其在COPD发病过程中的临床意义。方法分别检测并比较80例急性发作期入院的COPD患者及30例健康体检者(对照组)的外周血T细胞亚群及血清白介素(IL)-6、IL-8、TNF-α水平,将上述指标与第1秒用力呼气容积(FEV1)做相关性分析。结果COPD组总T细胞(CD3+)、Th细胞,Th／Ts比值、自然杀伤(NK)细胞均低于对照组,差异有统计学意义(P<0.05);COPD组入院时血清IL-8、IL-6和TNF-α水平明显高于对照组,差异有统计学意义(P<0.05);IL-6、IL-8、TNF-α与FEV1之间存在负相关(r值分别为-0.74,-0.69,-0.76,P<0.05)。结论T淋巴细胞亚群及细胞因子共同参与了COPD的炎性反应过程,其水平变化可作为监测病情的重要指标。
Abstract
Objective To study changes in T lymphocyte subsets of features and cytokine interleukin hormone (IL)-6,IL-8, tumor necrosis factor (TNF-α) in patients with chronic obstructive pulmonary disease (COPD) and the clinical significance. Methods Peripheral blood T cell subsets and serum IL-6,IL-8,TNF-α level were detected in admitted 80 patients with acute exacerbation of COPD and a control group of 30 healthy subjects.Analysis and comparison of the differences,and correlation with forced expiratory volume in one second (FEVI) were made.Results In COPD group, total T cells (CD3+), Th cells, Th / Ts ratio, natural killer (NK) cells were lower than those in control group, the difference was statistically significant (P<0.05). COPD group at time of admission had significantly higher serum IL-8, IL-6 and TNF-α levels , the difference was statistically significant (P<0.05); there were negative correlation between IL-6, IL-8, TNF-α and FEV1 (r=-0.74,-0.69,-0.76, P<0.05, respectively). Conclusion T lymphocyte subsets and cytokine are jointly involved in the inflammatory reaction in COPD,these changes play an important role in the development of COPD process,and can be used as an important indicator for monitoring of the disease.
关键词
慢性阻塞性肺疾病 /
T淋巴细胞亚群 /
细胞因子
Key words
chronic obstructive pulmonary disease /
T lymphocyte subsets /
cytokine
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