目的观察高通量血液透析联合左卡尼汀(L-carnitine)对尿毒症难治性贫血的治疗效果。方法将56例伴有难治性贫血的维持性血液透析(maintancehemodialysis，MHD)患者随机分为4组:普通透析组(14例)行普通血液透析治疗，每周3次;左卡尼汀组(14例)在普通血液透析基础上给予左卡尼汀1g，每周3次;高通量透析组(14例)行高通量血液透析，每周3次;高通量透析加左卡尼汀组(14例)在高通量透析基础上给予左卡尼汀1g，每周3次。治疗3、6个月后查血常规、生化指标，进行统计学分析。结果普通透析组和左卡尼汀组对患者的贫血没有改善;高通量透析组和高通量透析加左卡尼汀组贫血指标改善，与对照组比较有统计学意义(P＜0.05);高通量透析加左卡尼汀组与高通量组比较疗效显著，有统计学意义(P＜0.05)。结论4组中高通量透析联合左卡尼汀组能有效治疗尿毒症患者难治性贫血。
Abstract
Objective To study the effect of high-flux hemodialysis combined with levocarnitine on uremic pationts with refractory anemia. Methods Fifty-six patients with refractory anemia in maintenance hemodialysis were randomly divided into 4 groups: normal group ( 14 cases) underwent conventional hemodialysis, 3 times a week; L-carnitine group (14 cases) was given levocarnitine 1 g on common hemodialysis basis, 3 times a week; high-flux dialysis group (14 cases) received high- flux hemodialysis,3 times a week; high-flux hemodialysis plus L-carnitine group (14 cases) was given levocarnitine 1 g on high-flux hemodialysis basis, 3 times a week. Blood routine and biochemical indicators were examined after treatment for 3 and 6 months, and statistical analysis was made. Results The conventional hemo dialysis group and L-carnitine group had no improvement in anemia; high-flux hemo dialysis group and high-flux hemodialysis plus L-carnitine group improved in anemia, with statistically significant difference, compared with the conventional hemodialysis group (P＜0.05); high-flux hemodialysis combined with L-carnitine group, compared with high-flux hemodialysis group, had remarkable curative effect, with statistically significant difference ( P＜0.05 ). Conclusion High-flux hemodialysis combined with L-carnitine is effective in the treatment of uremic patients with refractory anemia
关键词
高通量血液透析 /
左卡尼汀 /
肾性贫血
Key words
high-flux hemodialysis /
L-carnitine /
renal anemia
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参考文献
[1] 雷建蓉.肾性贫血治疗的现状及展望[J].国外医学(移植与血液净化分册).2009.3(3):7-8.
[2] 王海燕.肾脏病血[M].3版.北京:人民卫生出版社,2008:1908-1909.
[3] Ayli D,Ayli M,Azak A,et al.The effect of high-flux hemodialysis on renal anemia[J].Nephrol,2004,17(5):701-706.
[4] Locatelli F,Martin-Malo A,Hannedouche T,et al.Effect of membrane permeability on survival of hemodialysis patients [J].J Am Soc Nephrol,2009,20:645-654.
[5] 侯 佳.高通量血液透析临床研究进展[J].新疆医学.2011.41(2):63-65.
[6] 韩艳芳,彭立人.肉碱对氧化应激状态的影响[J].国际移植与血液净化杂志,2006,11(6):43-45.
[7] Bellinghieri G,Santoro D,Calvani M,et al.Carnitine and hemodialysis[J].Am J Kidey Dis,2003,41(3):116-121.
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