目的探讨偏头痛患者磁共振弥散张量中脑白质损害。方法对17例偏头痛患者和16名健康志愿者，进行磁共振弥散张量成像(diffusiontensorimaging，DTI)检查。分别测定两组受试者的双侧额叶皮层下白质、双侧侧脑室旁周围白质和双侧枕叶皮层下白质中感兴趣区(regionofinterests，ROIs)的“看似正常的白质”(normalappearingwhitematter，NAWM)表观扩散系数(apparentdiffusioncoefficient，ADC)和各向异性分数(fractionalanisotropy，FA)，对两组数据进行比较分析。结果偏头痛组双侧侧脑室旁周围白质ADC值较对照组明显增高(P<0.05)，双侧枕叶皮层下白质各向FA值较对照组明显降低(P<0.01)。结论DTI有助于早期发现偏头痛患者的脑白质损害。
Abstract
Objective To study the white matter lesions in migraineurs by diffusion tensor imaging (DTI). Methods Seventeen migraineurs and sixteen healthy controls were recruited and examined with DTI in the General Hospital of PLA between February 2006 and April 2008. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in the normal appearing while matter(NAWM) of region of interests (ROIs) in frontal lobe, periventricular and occipital lobes were measured in each group. The data were analyzed by independent t-test. Results The ADC of periventricular NAWM in migraineurs was significantly higher than that in healthy controls(P<0.05). The FA of occipital lobe NAWM in migraineurs was significantly lower than that in healthy controls(P<0.01). Conclusion DTI is valuable to determine the early lesions of white matter in migraineurs .
关键词
偏头痛 /
脑白质损害 /
弥散张量成像
Key words
migraine /
white matter lesions /
diffusion tensor imaging
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