脑淀粉样血管病脑病理及其模型的研究进展

李志东,李文德综述叶静审校

武警医学 ›› 2013, Vol. 24 ›› Issue (7) : 635-636.

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PDF(651 KB)
武警医学 ›› 2013, Vol. 24 ›› Issue (7) : 635-636.
综述

脑淀粉样血管病脑病理及其模型的研究进展

  • 李志东1,李文德2综述叶静3审校
作者信息 +
文章历史 +

摘要

脑淀粉样血管病(cerebralamyloidangiopathy,CAA)是老年人的一种脑血管病。CAA的主要病理特点是有β-淀粉样蛋白(Aβ)沉着,其进一步发展可形成血管性痴呆。CAA患者常出现的临床表现包括与急性脑出血有关的神经功能突然缺失(脑卒中)、与短暂性脑缺血发作(transientischemicattack,TIA)相似的症状或痴呆[1]。CAA已成为老年人原发性、非外伤性、非高血压性脑出血的常见原因之一,严重威胁着老年人的健康。该病病因复杂,发病机制至今不清,临床诊断和治疗尚无突破性进展。但其病理学有一定特征,以脑萎缩、老年斑、神经纤维缠结以及皮层和海马中特异性神经递质缺失为特点。笔者将着重对CAA的脑病理及其模型进行综述。

关键词

脑淀粉样血管病 / 脑病理 / 模型

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李志东,李文德综述叶静审校. 脑淀粉样血管病脑病理及其模型的研究进展[J]. 武警医学. 2013, 24(7): 635-636
中图分类号: R743   

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基金

广东省科技计划项目(2006B36004015)


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