腹膜假黏液瘤的临床特征及预后因素分析

魏振军,李虹义,梁浩,罗继征

武警医学 ›› 2013, Vol. 24 ›› Issue (9) : 748-750.

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PDF(548 KB)
武警医学 ›› 2013, Vol. 24 ›› Issue (9) : 748-750.
论著

腹膜假黏液瘤的临床特征及预后因素分析

  • 魏振军1,李虹义1,梁浩2,罗继征1
作者信息 +

Clinical characteristics and prognostic analysis of pseudomyxoma peritonei

  • WEI Zhenjun1,LI Hongyi1,LIANG Hao2,and LUO Jizheng1.
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摘要

目的探讨腹膜假黏液瘤的临床特征及影响预后的因素。方法回顾性分析23例腹膜假黏液瘤的临床及随访资料,采用Kaplan-Meier法进行生存分析,Log-rank检验比较各样本生存期。结果主要症状为进行性腹胀、腹部包块、腹痛等。17例行腹腔减瘤术,3例行肿瘤细胞减灭术,9例行术后腹腔灌注化疗。总体3年、5年、10年生存率分别为79.7%、54.7%、27.3%,中位生存时间120个月。生存因素分析表明阑尾黏液性肿瘤病理类型与预后相关(P=0.012)。结论腹膜假黏液瘤术前确诊困难,综合应用腹部影像学等检查有助于诊断,手术联合腹腔灌注化疗是主要治疗方法,原发阑尾黏液性肿瘤性质影响腹膜假黏液瘤预后。

Abstract

Objective To investigate the clinical features and prognostic factors of pseudomyxoma peritonei(PMP). Methods The clinical characteristics and follow-up data of 23 patients with PMP admitted to the General Hospital of PLA in the past fourteen years were retrospectively analyzed.Survival analysis was evaluated through Kaplan-Meier and Log-rank tests. Results The mean age was 56.6±12.8 (range 36~75)(57%male, 43%female). Abdominal distension, mass and pain were major symptoms. Ascites and mass were often found in the examination of abdominal imaging such as CT and ultrosonography. Of 23 patients,17 underwent debulking surgery and 3 had complete cytoreductive surgery. Intraperitoneal chemotherapies were followed after surgery in 9 patients. Survival analysis(Kaplan-Meier method) showed that the median survival time was 120.0 months and 3-,5-,10-years survival rates were 79.7%,54.7%,27.3%,respectively. Survival time of patients was closely correlated with primary appendiceal neoplasm. Conclusions Preoperative diagnosis of PMP is difficult, imagings including CT and ultrasonography are beneficial to the definite diagnosis. Pathological type of appendiceal mucinous neoplasm affects the survival of patients with PMP.Surgery combined with intraperitoneal chemotherapy is the standard treatment and can improve short-term outcome. Long-term survival is not achieved well.

关键词

腹膜假黏液瘤 / 预后 / 单因素分析

Key words

pseudomyxoma peritonei / prognosis / univariate analysis

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魏振军,李虹义,梁浩,罗继征. 腹膜假黏液瘤的临床特征及预后因素分析[J]. 武警医学. 2013, 24(9): 748-750
WEI Zhenjun,LI Hongyi,LIANG Hao,and LUO Jizheng.. Clinical characteristics and prognostic analysis of pseudomyxoma peritonei[J]. Medical Journal of the Chinese People Armed Police Forces. 2013, 24(9): 748-750
中图分类号: R735.36    R735.5   

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