目的对比观察急性脑梗死(combinedintra-arterial，ACI)超早期行动静脉联合溶栓与静脉溶栓的临床疗效及安全性。方法系统性回顾分析68例行动静脉联合溶栓或静脉溶栓治疗的ACI患者的临床资料，比较两组术后闭塞血管再通率、术后NIHSS评分、并发症等。结果联合组、静脉组患者术后7d与术前相比，NIHSS评分差异均有统计学意义(P<0.05或P＜0.01)。两组患者术后24h、术后7dNIHSS评分相比，差异有统计学意义(P<0.05);两组患者术后闭塞血管再通率相比，差异有统计学意义(P<0.05);两组患者术后出血发生率及病死率相比，差异无统计学意义(P>0.5)。结论对于ACI的治疗，动静脉联合溶栓的疗效优于静脉溶栓。

Objective To evaluate the safety and efficacy of combined intra-arterial/intravenous thrombolysis versus intravenous thrombolysis for treatment of ACI in early stage. Methods The clinical data of pre-operation, postoperation and long-term follow-up of 68 patients with ACI were systematically reviewed. Results In combined thrombolysis group, there was significant difference in NIHSS score between postoperative and preoperative periods(P<0.05). In intravenous thrombolysis group, there was significant difference in NIHSS score between postoperative and preoperative periods (P<0.01). There was significant difference in postoperative NIHSS score between the two groups(P<0.05). There was significant difference in the rate of recanalization between the two groups(P<0.05). The difference in the rate of complications and mortality between the two groups was not significant(P>0.05). Conclusions The treatment of acute ischemic stroke with combined intra-arterial/ intravenous thrombolysis is better than .intravenous thrombolysis alone.