目的 探讨阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome, OSAS)对老年糖尿病患者血糖的影响。方法 采用RS2611床垫式睡眠呼吸监测系统监测老年糖尿病患者80例睡眠呼吸状况, 分析OSAS对血糖的影响。结果 合并OSAS的患者空腹血糖、餐后2 h血糖、糖化血红蛋白、C反应蛋白(C-reactive protein , CRP)及同型半胱氨酸(homocysteine, Hcy)均较非OSAS患者增高, 且OSAS越重, 各测定值水平越高, 差异有统计学意义(P＜0.05或P＜0.01)。空腹及餐后2 h血糖、糖化血红蛋白、Hcy、CRP与睡眠呼吸暂停低通气指数(apnea-hypopnea index , AHI)呈正相关, 与夜间最低血氧饱和度(LO₂)呈负相关。结论 OSAS病情越重, 患者血糖水平越高, OSAS可能是糖尿病患者血糖紊乱的独立危险因素。

Objective To study the effect of obstructive sleep apnea syndrome (OSAS) on blood glucose in elderly patients with diabetes mellitus. Methods Eighty elderly diabetic patients were monitored by RS2611 mattress monitoring system of sleep. The data of sleep disordered breathing and relationship between OSAS and blood glucose were analyzed. Results Compared with the non-OSAS patients, all the OSAS patients showed increased fasting and 2-hour postprandial plasma glucose, HbA₁c, CRP and homocysteine. The increments were statistically significantly different in severe OSAS patients and were correlated with different parameters of breathing function during sleep. Conclusions OSAS may produce harmful effect on blood glucose in elderly patients.