目的 探讨老年男性患者血清脂蛋白(a)[lipoprotein(a),LP(a)]水平变化与五种代谢性疾病之间的关系,为老年男性患者疾病的诊治提供依据。方法 以2011-06至2012-12在武警总医院住院的442例老年男性患者为研究对象,随机抽取同期健康体检老年男性80例为对照组,应用胶乳凝集比浊法测定观察血清LP(a)变化。结果 对照组血清LP(a)水平为(154±110)mg/L,在高血压、糖尿病、冠心病、脑梗死及肾功能不全组则分别为(255±191)mg/L、(266±174)mg/L、(341±342)mg/L、(335±277)mg/L、(296±235)mg/L,较对照组明显升高,差异均有统计学意义(P＜0.05);对照组患者LP(a)异常比例为6.3%,在高血压、糖尿病、冠心病、脑梗死及肾功能不全组则分别为25.7%、38.9%、52.4%、42.3%、37.2%,较对照组明显升高,差异均有统计学意义(P＜0.05);按照年龄分组,60~69岁、70~79岁、≥80岁患者各年龄组LP(a)水平无统计学意义。结论 血清LP(a)升高参与老年男性患者高血压、糖尿病、冠心病、脑梗死及肾功能的病理过程,该变化与年龄段无关。

Objective To investigate the level changes of serum lipoprotein(a),further to provide the evidence for early diagnosis in the elderly male patients. Methods 442 hospitalized elderly male patients between June 2011 and December 2012 were enrolled in this study. Other 80 healthy elderly male subjects served as control group. The levels of serum Lp(a) were measured by latex agglutination turbidimetric method. Results Compared with the control group, the level of Lp(a) was significantly increased in disease group( P＜0.05 ),the levels of Lp (a) in control group was(154±110)mg/L,the level of Lp (a) in the high blood pressure,diabetes mellitus,coronary heart disease,cerebral infarction and renal insufficiency group respectively were(255±191),(266±174),(341±342),(335±277), and (296±235)mg/L respectively. The abnormal ratio in control serum was 6.0%, the abnormal ratios in the high blood pressure, diabetes mellitus, coronary heart disease,cerebral infarction, and renal insufficiency groups were 25.7%, 38.9%, 52.4%, 42.3%, and 37.2 %, respectively; the differences were statistically significant as compared with the control group (P＜0.05). The LP (a) levels of age group were no statistical difference. Conclusions The levels of serum LP (a) are significantly increased in elderly male patients with high blood pressure,diabetes,coronary heart disease,cerebral infarction, and renal insufficiency, regardless of age.