小檗碱降糖调脂机制新进展

肖新华,张 茜

武警医学 ›› 2014, Vol. 25 ›› Issue (2) : 109-112.

PDF(809 KB)
PDF(809 KB)
武警医学 ›› 2014, Vol. 25 ›› Issue (2) : 109-112.
专家论坛

小檗碱降糖调脂机制新进展

  • 肖新华,张 茜
作者信息 +
文章历史 +

引用本文

导出引用
肖新华,张 茜. 小檗碱降糖调脂机制新进展[J]. 武警医学. 2014, 25(2): 109-112
中图分类号: R587.1   

参考文献

[1] 倪艳霞. 黄连素治疗Ⅱ型糖尿病60例疗效观察及实验研究[J].中国中西医结合杂志,1988,8(12):711-713.

[2] 王 强.黄连素片治疗糖尿病的体会[J].中医药信息,2008,2:35.

[3] 陈德元.黄连素治疗2 型糖尿病50 例观察[J].现代中西医结合杂志,2012,10(2):138-139.

[4] Zhou J Y, Zhou S W. Effect of berberine on glucolipid metabolization in diabetic skeletal muscle and its mechanism[J].J Chin Pharmaceutical Sciences,2011,16(4):300-306.

[5] 于棉荣,张少时,张佩文,等.黄连素治疗糖尿病105例疗效观察[J].中国民间疗法,1996,3:31-32.

[6] 石利天,张瑞增.黄连素治疗68例2 型糖尿病的临床评价[J].山西临床医药杂志,2011,9(3):181-182.

[7] Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus[J].Metabolism,2008,57(5):712-717.

[8] 李 真.生地黄连液对四氧嘧啶小鼠影响的研究[J].辽宁中医杂志,2000,27(12):574.

[9] 陈其明,谢明智.黄连及黄连素降血糖作用的研究[J].药学学报,1986,21(6):401.

[10] Lee Y S, Kim W S, Kim K H, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states[J].Diabetes,2012,55(8): 2256- 2264.

[11] Ko B S, Choi S B, Park S K, et al. Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizome[J]. Biol Pharm Bull,2005,28:1431-1437.

[12] Cheng Z, Pang T, Gu M, et al. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK[J]. Biochim Biophys Acta,2006,1760:1682-1689.

[13] Zhou L, Yang Y, Wang X, et al. Berberine stimulates glucose transport through a mechanism distinct from insulin[J]. Metabolism,2010,56:405-412.

[14] Kim S H, Shin E J, Kim E D, et al. Berberine activates GLUT1-Mediated glucose uptake in 3T3-L1 adipocytes[J].Biol Pharm Bull,2007,30:2120-2125.

[15] Kong L D, Cheng C H, Tan R X. Monoamine oxidase inhibitors from rhizoma of Coptis chinensis[J]. Planta Med,2011,67:74-76.

[16] Pospisilik J A, Knauf C, Joza N, et al.Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes[J].Cell,2007,131:476-491.

[17] Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol -lowering drug working through a unique mechanism distinct from statins[J]. Nat Med,2012,10(12):1344-1351.

[18] Cicero A F, Rovati L C, Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol –lowering agents. A single-blind clinical investigation[J]. Arzneimittelforschung,2007,57:26-30.

[19] Yin J, Chen M, Tang J,et al. Effects of berberine on glucose and lipid metabolism in animal experiment[J]. Chin J Diabetes,2004,12(3):215-218.

[20] Leng S H, Lu F E, Xu L J. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion[J]. Acta Pharmacol Sin,2004,25(4):496-502.

[21] 勾祥辉.黄连素治疗高血脂59例[J].人民军医,2008,2(1):35.

[22] 宋菊敏,毛 良,施建玲,等.黄连素对非胰岛素依赖性糖尿病大鼠的抗氧化作用[J].中草药,1992,23(11):590.

[23] 殷 峻,陈明道,唐金凤,等.黄连素对实验大鼠糖脂代谢的影响[J].中华糖尿病杂志,2012,12(3):215-218.

[24] Rosen E D, MacDougald O A. Adipocyte differentiation from the inside out[J].Nat Rev Mol Cell Biol,2006,7(12):885-896.

[25] Abidi P, Zhou Y, Jiang JD,et al.Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine[J]. Arterioscler Thromb Vasc Biol,2005,25(10):2170-2176.

[26] Lee S, Lim H J, Park H Y,et al.Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo[J]. Atherosclerosis,2006,186(1):s29-37.

[27] Liang K W, Ting C T, Yin S C, et al. Berberine suppresses MEK/ERKdependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury[J].Biochem Pharmacol,2006,71(6):806-817.

[28] Lee S, Lim H J, Park J H,et al. Berberine-induced LDLR up-regulation involves JNK pathway[J].Biochem Biophys Res Commun,2007,362(4):853-857.

[29] Zhou J Y, Zhou S W. Effect of berberine on glucolipid metabolization in diabetic skeletal muscle and its mechanism[J]. J Chin Pharmaceutical Sciences,2011,16(4):300-306.

[30] Choi B H, Ahn I S, Kim Y H, et al. Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte[J]. Exp Mol Med,2012,38(6):599-605.

基金

国家自然科学基金(81170736,81300649)


PDF(809 KB)

Accesses

Citation

Detail

段落导航
相关文章

/