目的 评价胃窦黏膜淋巴滤泡增生在幽门螺杆菌性胃炎病理诊断中的价值。方法 以淋巴滤泡增生为诊断幽门螺杆菌性胃炎的标准,与诊断幽门螺杆菌阳性的“金标准”进行临床流行病学分析。结果 在1385例慢性胃炎中,以淋巴滤泡增生为诊断幽门螺杆菌性胃炎标准,其诊断的准确度为79.35%,灵敏度为79.43%,特异度为79.18%,阳性预告值89.22%,阳性似然比3.93,漏诊率为20.57%,误诊率为20.82%,阴性预告值79.18%,阴性似然比0.26。结论 淋巴滤泡增生是幽门螺杆菌性胃炎的组织病理形态学特征之一,是诊断幽门螺杆菌性胃炎的重要组织学依据,但不是唯一标准。

Objective To evaluate the pathological diagnostic values of lymphoid follicle heperplasia in chronic gastritis with Helicobacter pylori infection. Methods Clinical epidemiology was conducted to analyse the results of lymphoid follicle heperplasia as diagnostic criteria to scan and compare with “golden standard” of histopathologic diagnosis of chronic gastritis. Results Using lymphoid follicle heperplasia as diagnostic standard to diagnose Helicobacter pylori infective gastritis, the diagnostic accuracy was 79.35% in 1385 cases, the sensitivity was 79.43%, the specificity was 79.18%,the positive predictive value was 89.22%, positive likelihood ratio was 3.93. The misdiagnostic rate was 20.82% in 1385 cases , under diagnostic rate was 20.57%,the negative predictive value was 79.18%,and negative likelihood ratio was 0.26. Conclusions Lymphoid follicle heperplasia is proved to be one of classical histopathological morphologic features of chronic gastritis with Helicobacter pylori infection. It can serve as one of the important markers for pathological diagnosis,but not the only one.