目的探讨研究B型尿钠肽(Brain natriuretic peptide, BNP)水平升高对脓毒血症患者预后的预测价值。方法 检索Pubmed, Embase, Cochrane中心对照试验和CNKI中国期刊全文数据库, 纳入2012年12月以前有关脓毒血症患者BNP水平的研究文献, 并用Revman 5软件进行Meta分析。结果 纳入8项研究共1464例, Meta分析结果表明脓毒血症患者BNP水平升高与患者死亡风险明显相关, 比值比(odds ratio, OR)为10.44, 95%置信区间(4.99, 21.85)。结论 脓毒患者BNP水平是强有力的死亡风险评估指标, 进一步研究需要大样本的前瞻性研究来保证其评估过程的标准化。

Objective By this systematic review and meta-analysis to investigate the value of elevated BNP in predicting mortality in septic patients. Methods Pubmed, Embase, the Cochrane Central Register of Controlled Trials and CNKI were searched(up to December, 2012).Studies on prospectively clollected data of all-cause mortality in adult septic patients with BNP measurement were included and analyzed by Revman 5.0. Results Eight studies with a total of 1464 patients were included. Elevated natriuretic peptides in sepsis patients were significantly associated with increased risk of mortality [odds ratio(OR) 10.44, 95% CI (4.99, 21.85)]. Conclusions Elevated BNP level may prove to be a powerful predictor of mortality in septic patients.Further large and more adequately powered prospective studies are warranted to clarify the assay standardization.