目的探讨冲击放射治疗(放疗)联合破骨细胞抑制药对骨转移性疼痛的镇痛效果。方法 恶性肿瘤伴骨转移疼痛患者550例分为两组, 其中治疗组300例接受冲击放疗联合破骨细胞抑制药治疗, 对照组250例仅用破骨细胞抑制药或其他药物进行治疗。结果 疼痛部分或完全缓解近期有效率为75.6%, 对照组为39.6%, 差异有统计学意义(P＜0.05);治疗组远期有效率为85.6%, 对照组为48.8%, 差异有统计学意义(P＜0.05)。结论 冲击放疗联合破骨细胞抑制药对骨转移性疼痛近期和远期有良好的镇痛效果。
Abstract
Objective To investigate the clinical effects of high dose radiotherapy combined with osteoclast inhibitors on pain caused by osseous metastasis. Methods 550 malignant tumor patients were divided into treatment group(n=300) and control group(n=250).Treatment group was given high dose radiotherapy combined with osteoclast inhibitors.The control group was only received osteoclast inhibitors or else drugs. Results The efficiency of partial response plus complete response was significantly higher in treatmen group than those in control group (75.6% vs 39.60%, P<0.05). And the long-term response rate was also better than that in control group (85.6% vs 48.8%, P<0.05). Conclusions High dose radiotherapy combined with osteoclast inhibitors has good short and long-term clinical efficacy for pain caused by osseous metastasis.
关键词
冲击放疗 /
破骨细胞抑制药 /
骨转移 /
止痛
Key words
high fraction radiotherapy /
osteoclast inhibitors /
osseous metastatic /
bone pain
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参考文献
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