目的 采用Meta分析的方法评价转化生长因子β₁(transforming growth factor beta1,TGF-β₁)基因-509C/T多态性与牙周炎的相关性。方法 计算机检索PubMed、EMbase、中国知网、万方和中国生物医学文献数据库,查找国内外公开发表的TGF-β₁基因-509C/T多态性与牙周炎相关性的病例-对照研究,检索时限均为1990-01-01至2013-08-08,并追溯纳入文献的参考文献,由2位评价员独立进行文献筛选、资料提取和质量评价后,采用Stata12.0软件进行Meta分析。结果 最终纳入4个病例-对照研究,包括牙周炎患者342例,对照组347例。Meta分析结果显示,各基因模型均无统计学意义。C/T vs. C/C, OR=0.83, 95%CI=0.59-1.17, P=0.29; T/T vs. C/C, OR=0.66, 95%CI=0.29-1.50, P=0.32;(C/T+T/T) vs. C/C, OR=0.78, 95%CI=0.55-1.12, P=0.18;T/T vs. (C/T+C/C), OR=0.75, 95%CI=0.32-1.72, P=0.49;T vs. C, OR=0.83, 95%CI=0.60-1.16, P=0.50。结论 TGF-β₁基因-509C/T多态性可能与牙周炎发病无关。

Objective To evaluate the association between periodontitis and-509C/T polymorphism in transforming growth factor beta1 (TGF-β₁) gene. Methods The PubMed, EMbase, CNKI, WanFang, and CBM databases were searched from January 1, 1990 to August 8, 2013 to collect case-control studies about the relationship between periodontitis and-509C/T polymorphism in TGF-β₁ gene. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted data, evaluated the quality. Then the meta-analysis was conducted using Stata12.0 software. Results A total of 4 case-control studies involving 342 in periodontitis and 347 healthy volunteers were included. The Results of meta-analysis showed that there was no statistically significant association between-509C/T polymorphism and periodontitis. For C/T vs. C/C, OR=0.83, 95%CI=0.59-1.17, P=0.29; for T/T vs. C/C, OR=0.66, 95%CI=0.29-1.50, P=0.32; for (C/T+T/T) vs. C/C, OR=0.78, 95%CI=0.55-1.12, P=0.18; for T/T vs. (C/T+C/C), OR=0.75, 95%CI=0.32-1.72, P=0.49; for T vs. C, OR=0.83, 95%CI=0.60-1.16, P=0.50. Conclusions The-509C/T polymorphism in TGF-β₁ gene may have no association with periodontitis.