目的 对胚胎停止发育患者在生活和工作中接触到的某些危险因素进行分析,探讨其对胚胎停止发育的影响,为预防胚胎停止发育提供科学依据。方法 选取2010-06至2012-06诊断为胚胎停止发育患者60例为病例组,胚胎正常发育者60例为对照组,对以上两组孕妇予以问卷调查,内容涉及基本情况、生活习惯、生活和工作环境中各种因素等,对搜集到的资料进行t检验、 χ²检验和非条件Logistic回归分析。结果 既往流产史、每日使用辐射性电器的时间、睡眠不足6 h/d、饮酒、吸烟等十项因素与胚胎停止发育的发生率相关(P＜0.05),采用非条件Logistic回归法进一步分析,有流产史(OR=18.254)、使用辐射性电器的时间2～6 h/d(OR=43.067)和＞6 h/d(OR=94.886)、经常睡眠不足6 h/d(OR=9.017)、经常饮酒(OR=7.602)、经常吸烟(OR=7.573)、进行适量体育锻炼(OR=0.151)、孕期心情抑郁(OR=46.025)、工作强度较大(OR=108.003)有统计学意义(P＜0.05)。结论 有流产史、使用辐射性电器的时间＞2 h/d、有经常睡眠＜6 h/d、饮酒、吸烟的情况、孕期心情抑郁、工作强度较大等可能是导致胚胎停止发育的危险因素,进行适量体育锻炼可能是预防胚胎停止发育的保护因素。

Objective To investigate some rick factors with embryonic arrest met with in living and working and discuss the influence of the factors on embryonic arrest to provide some scientific evidence for preventing embryonic arrest. Methods Sixty women with embryonic arrest were recruited as the case group while 60 women with normal pregnancy as the control group. One questionnaire survey to the two groups was conducted and the data were analyzed by t-test, χ² test and logistic regression analysis. Result The incidence rate of embryonic arrest was related with 10 different factors, such as history of abortion, using time of the radioactive electrical equipment, sleep time＜6 h/d, smoking, drinking, et al. (P＜0.05).Logistic regression analysis revealed that the factors such as history of abortion (OR=18.254), using time of the radioactive electrical equipment 2-6 h/d(OR=43.067), ＞6 h/d(OR=94.886),sleep time＜6 h/d often(OR=9.017), smoking often(OR=9.017), drinking often(OR=7.602), getting moderate exercise (OR=0.151), feeling depression during pregnancy (OR=46.025)and intense work (OR=108.003) were related to embryonic arrest(P＜0.05 ). Conclusion With a history of abortion,using time of the radioactive electrical equipment＞2 h/d, sleep time＜6 h/d often, smoking and drinking frequently, feeling depressed during pregnancy and intense work might be the rick factors causing embryonic arrest while getting moderate exercise might be the protective factor preventing embryonic arrest.