目的 观察复方丹参滴丸对初发2型糖尿病患者尿微量白蛋白排泄率(urinary albumin excretion rate, UAER)的影响。方法 2005-05-12选择门诊和住院初发2型糖尿病患者68例,入组前均未诊治。随机分为对照组(35例)和丹参组(33例)。比较治疗期间UAER变化,并分析与糖化血红蛋白(HbA₁c)、血脂、血压等关系。结果 (1)第5年、7年时对照组患者血总胆固醇(TC)与治疗前比较明显减低(P<0.05),对照组低密度脂蛋白(LDL-C)治疗5年后与治疗前比较降低明显(P<0.05)。丹参组治疗7年后高密度脂蛋白(HDL-C)、三酰甘油(TG)与治疗前比较有明显差异(P<0.05),但两组患者7年前后的空腹血糖(FPG)、HbA₁c、血压及血脂水平同期比较均无统计学差异。(2)两组UAER均逐渐增高,治疗5年、7年后两组与治疗前比较均有统计学差异(P<0.01),治疗7年后丹参组(22.31±3.14)mg/24 h增高低于对照组(25.81±3.83)mg/24 h。(3)治疗7年后,对照组糖尿病肾病发生率(33.3%)高于丹参组(10.0%),差异有统计学意义(P<0.05)。结论 复方丹参滴丸治疗可延缓糖尿病肾病的发生及发展。

Objective To investigate the effect of Compound Danshen Dripping Pills on type 2 diabetic patients with urinary ablumin excretion rate. Methods 68 patients were recruited between May and December 2005 from courtyard outpatients and hospitalized patients, who did not take hypoglycemic drugs. Followed up for 7 years, these patients were randomly divided into two groups: saline group blood glucose, blood pressure, blood lipid control group (35 cases), Danshen group in the saline group on the basis of Compound Danshen Dripping Pills (33 cases). During treatment urinary albumin excretion rate, and the relationships between glycosylated hemoglobin, blood lipids, blood pressure were investigated. Results (1) After five years, and 7 years of treatment, total cholesterol was significantly lowered compared with before(P<0.05), low density lipoprotein saline group after 5 years of treatment compared with before treatment was significantly reduced(P<0.05). In the Danshen group after 7 years of treatment, high density lipoprotein, triglyceride and before treatment were significantly different(P<0.05), But in the two groups of patients before and after 7 years, the average blood glucose, glycosylated hemoglobin, blood pressure and blood lipid levels were not statistically different compared with the same period. (2) In the two groups, urinary albumin excretion rates were increased, 5 years, 7 years after, in the two groups as compared with that before treatment, differences were significant (P<0.001). (3) In the two groups, diabetic nephropathy patients all increased, but the incidence rate in Danshen group was lower than that in control group(10.0% vs 33.3%, P<0.05). Conclusions Compound Danshen dripping pills therapy can retard the occurrence and development of diabetic nephropathy.