目的 探讨放疗剂量对早期鼻腔NK/T细胞淋巴瘤预后的影响。方法 将64例早期鼻腔NK/T细胞淋巴瘤患者,根据放疗剂量大小分为＜50 Gy组(n=20),51～60 Gy组(n=24)和＞60 Gy组(n=20),观察比较各组局部控制率和5年生存率。结果 经随访＜50 Gy组局部控制率68.5%,5年生存率42.1%。51～60 Gy组局部控制率达到82.5%,生存率达60.9%。两组对比在局部控制率和5年生存率有统计学意义(P＜0.05),但51～60 Gy组和＞60 Gy组对比无统计学意义。结论 以51～60 Gy剂量的放疗能保证良好的局部控制率,提高患者总生存率,建议临床在选择放疗剂量时以51～60 Gy为宜。

Objective To study the effects of different radiotherapy doses on the early stage nasal NK/T cell lymphoma. Methods 64 patients with early stage nasal NK/T cell lymphoma undergoing radiotherapy were divided into <50 Gy group(n=20), 51-60 Gy group(n=24) and ＞60 Gy group(n=20), all groups were observed and their local control rate and survival rate of 5 years were compared. Results The total local control rates in the three groups were 68.5%, 82.5% and 72.2% respectively. There was significant difference in the local control rate and survival rate of 5 years between＜50 Gy group and the other two groups (51-60 Gy and ＞60 Gy group) (P＜0.05), but the differences between the two groups were not statistically significant. Conclusions 51-60 Gy doses of radiation can guarantee good local control rate, improve overall survival rate. The choice of radiation doses to 50 Gy in patients with early stage nasal NK/T cell lymphoma is appropriate, with clinical recommendations.