目的 分析血液病患者血小板输注无效(platelet transfusion refractoriness,PTR)原因,以提高血小板输注率。方法 分析血液病患者PTR的临床特征,比较输注单采血小板+少白细胞红细胞(少白组)、单采血小板+悬浮红细胞(悬浮组)、单采血小板(单采组)患者的血小板输注疗效。结果 93例血液病患者PTR率平均为25.0%。少白组、悬浮组、单采组的PTR率分别为21.2%、32.7%、 26.7%(χ²=5.66),结果无统计学意义,但少白组有低于其他两组的趋势。结论 影响血液病患者PRT原因虽然有非免疫性因素,而减少输入白细胞数量可提高血小板输注。

Objective To analyze the reasons of invalid blood platelets transfusion in patients with hematological diseases, in order to improve the rate of blood platelet transfusion. Methods The clinical features of patients with invalid blood platelets transfusion were analyzed. Curative rates of infusing platelets + less leukocyte suspension (less leukocyte group), platelets + suspended red blood cells (suspension group), and platelets alone group (platelets group) were compared. Results Blood platelet invalid infusion rate was 25.0% on average in 93 patients. In less leukocyte group, suspension group, and platelets alone group, the platelet infusion inefficient rates were 21.2%, 32.7% and 26.7%, respectively (χ²=5.66, P＞0.05); the Results has no statistically significant difference. But the tendency in the less leukocyte group was lower than those in the other two groups. Conclusions These factors affect patients with invalid blood platelets transfusion despite non immunologic factor. Reducing the number of white blood cells can improve the blood platelet transfusion.