目的探讨癌胚抗原(carcinoembryonic antigen ,CEA)、神经元特异度烯醇化酶(neuron-specific enolase degree ,NSE)、磷状上皮细胞癌抗原(squamous cell carcinoma antigen ,SCC-Ag)与细胞角蛋白19片段(cytokeratin 19 fragment ,CYFRA21-1)联合检查对肺癌的诊断价值。方法选取肺癌68例,同时选取良性肺疾病70例和健康体检人员90名作为对照组和健康组,分别应用全自动发光免疫分析仪开展血清检查,记录三组样本血清中的CEA、NSE、SCC-Ag与CYFRA21-1的含量,并进行比较分析。结果肺癌组的血清CEA、NSE、SCC-Ag与CYFRA21-1含量均显著高于其他两组,组间比较差异有统计学意义(P<0.05)。单一检测的特异性较高,与联合诊断比较无统计学差异,但联合诊断的灵敏度为80.9%,准确度为83.3%,均显著高于单一检测,差异有统计学意义(P<0.05)。结论血清CEA、NSE、SCC-Ag与CYFRA21-1的联合检查能有效提高肺癌诊断的敏感性和准确度,具有较好的诊断价值。

Objective To investigate the joint clinical value of carcinoembryonic antigen (CEA), neuron-specific enolase degree (NSE), squamous cell carcinoma antigen (SCC-Ag) and cytokeratin 19 fragment (CYFRA21-1) in diagnosis of lung cancer patients. Methods 68 patients with lung cancer in this hospital from September 2012 to August 2013 were recruited , while 70 patients with benign lung disease and 90 healthy people as controls ,underwent automated immunoassay analyzer serological test.Two samples of serum CEA, NSE, SCC-Ag and content CYFRA21-1 were recorded to conduct comparative analysis. Results After testing, serum CEA in lung cancer group , NSE, SCC-Ag and CYFRA21-1 levels were significantly higher than those in the other two groups, the difference was statistically significant (P<0.05) between groups . The CEA level in adenocarcinoma was significantly higher than that in the other two types; NSE level in small cell lung cancer was significantly higher than that in the other two types; SCC-Ag and CYFRA21-1 levels in squamous cell carcinoma were significantly higher than those in the other two types , the differences were statistically significant (P＜0.05). High single detection specificity had no significant difference in the joint diagnosis, but the combined diagnostic sensitivity was 80.9 % and the accuracy was 83.3% , significantly higher than those in a single test, the difference was statistically significant (P<0.05 ). Conclusions The serum lung cancer patients carry CEA, NSE, SCC-Ag and CYFRA21-1 joint diagnosis could effectively improve the sensitivity and accuracy of disease diagnosis , with the exact value of clinical application.