目的探讨心脏神经官能症患者心、脑血管疾病风险。方法心脏神经官能症(cardiac neurosis,CN)42例作为CN组,健康体检者41例作为对照组,比较两组心率变异性(HRV)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和肱动脉内皮依赖性舒张功能(EDD)。结果两组HRV各项参数比较有统计学差异(P＜0.05);CN组hs-CRP、TNF-α和EDD分别为(1.96±0.37) mg/L、(21.3±6.5) ng/ml、(5.25±0.53)%,对照组为(1.09±0.24) mg/L、(9.6±2.3) ng/ml、(9.12±2.16)%,两组间两两比较均有统计学差异(P＜0.05)。结论心脏神经官能症患者存在多种心、脑血管疾病发病危险因素。

Objective To study the risk of cardio-cerebrovascular diseases in patients with cardiac neurosis by comparing the HRV、hs-CRP、TNF-α and EDD with normal controls. Methods The differences of HRV、hs-CRP、TNF-αand EDD between 42 patients with cardiac neurosis (CN group) and 41 normal controls (control group) were observed. Results There were significant differences in parameters of HRV(P＜0.05). The result of hs-CRP in CN group was (1.96±0.37)mg/L while that in control group was (1.09±0.24)mg/L,The result of TNF-α in CN group was (21.3±6.5)ng/ml while that in control group was (9.6±2.3)ng/ml, The result of EDD in CN group was (5.25±0.53)% while that in control group was(9.12±2.16)%, Increase of hs-CRP and TNF-α,decrease of EDD in CN group were significantly different(P＜0.05). Conclusions There was positive risk of cardio-cerebrovascular disease in patients with cardiac neurosis.