IgA肾病临床表现、发病机制及诊治进展

刘景铎

武警医学 ›› 2014, Vol. 25 ›› Issue (9) : 865-868.

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武警医学 ›› 2014, Vol. 25 ›› Issue (9) : 865-868.
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IgA肾病临床表现、发病机制及诊治进展

  • 刘景铎
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摘要

IgA肾病(IgA nephropathy, IgAN)是一种世界性的常见肾小球肾炎[1],主要特征是免疫球蛋白A(immune globulin A, IgA)沉积在肾小球系膜区,并引发肾病。1968年,Berger首先描述本病,故又称Berger病[2]。基于13 519份肾活检结果的统计,在我国IgAN发病率约占原发性肾小球疾病的45.26%[3]。遗传、环境和地域与发病的关系尚在进一步研究中[4]

关键词

IgA肾病 / 肾病综合征 / 肾小球肾炎 / 蛋白尿

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导出引用
刘景铎. IgA肾病临床表现、发病机制及诊治进展[J]. 武警医学. 2014, 25(9): 865-868
中图分类号: R692.3   

参考文献

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[8] Alamartine E, Sabatier J C, Berthoux F C. Comparison of pathological lesions on repeated renal biopsies in 73 patients with primary IgA glomerulonephritis: value of quantitative scoring and approach to final prognosis [J]. Clin Nephrol, 1990, 34(2): 41-45.
[9] Maschio G, Cagnoli L, Claroni F, et al. ACE inhibition reduces proteinuria in normotensive patients with IgA nephropathy: a multicentre, randomized, placebo-controlled study[J]. Nephrol Dial Transplant, 1994, 9(3): 265-269.
[10] James P A, Oparil S, Barry L. et al. 2014 evidence-based guideline for the management of high blood pressure in adults[J]. JAMA, 2013, 311(5): 507-520.
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[12] Liu Y, Liu H, Tu X, et al. Study of tonsillectomy for IgA nephropathy patients: short- and longer-term observation[J]. Int Urol Nephrol, 2013, 23(11): 982-986.

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