目的 探讨可溶性血管黏附分子1(soluble vascular cell adhesion molecule-l,sVCAM-1)、妊娠血浆相关蛋白-A(pregnancy associated plasmaprotein A,PAPP-A)和白细胞介素6(interleukin-6,IL-6)在妊娠高血压综合征(妊高征)发病中的作用。方法 选取92例妊娠期高血压疾病孕妇(其中妊娠期高血压50例,子痫前期30例,子痫12例)和80例健康孕妇为对照组,检测其sVCAM-1、PAPP-A和IL-6水平。结果 子痫前期、子痫患者血清sVCAM-1、PAPP-A和IL-6水平显著高于对照组(P<0.01),子痫前期、子痫患者sVCAM-1和PAPP-A有显著正相关性(r=0.85, P<0.05), IL-6和sVCAM-1呈正相关(r=0.64, P<0.05)。结论 sVCAM-1、PAPP-A和IL-6与妊娠期高血压疾病发作进展存在明显关联性,可推广性应用于实际临床工作,提高子痫早期诊疗率,降低孕产妇及围生儿病死率。
Abstract
Objective To investigate the roles of soluble vascular cell adhesion molecule-l(sVCAM-1), pregnancy associated plasmaprotein A(PAPP-A) and interleukin-6(IL-6) in pregnancy-induced hypertension. Methods Ninety-two pregnant woman diagnosed as having pregnancy-induced hypertension were recruited and divided into gestational hypertension group(50 cases), preeclampsia group(30 cases)and eclampsia group(12 cases). Eighty healthy pregnant women were set as controls. sVCAM-1、PAPP-A were measured by chemiluminescence and IL-6 was measured by radioimmunoassay. Results The levels of sVCAM-1, PAPP-A and IL-6 in preeclampsia group and eclampsia group were significantly higher than those in control group(P<0.01). The levels of sVCAM-1 and PAPP-A had significant correlation in groups of preeclampsia and eclampsia(r=0.85, P<0.05), and the levels of IL-6 and sVCAM-1 had positive correlation in groups of preeclampsia and eclampsia(r=0.64, P<0.05).Conclusions SVCAM 1, PAPP - A and IL - 6 have obvious ralationship with gestational hypertension. They can be applied in the clinical generalization, increase the rate of early diagnosis and treatment of eclampsia and reduce maternal and perinatal mortality.
关键词
高血压 /
可溶性血管黏附分子1 /
妊娠血浆相关蛋白-A /
白细胞介素6
Key words
hypertension /
soluble vascular cell adhesion molecule-l /
pregnancy associated plasmaprotein A /
interleukin-6
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