目的 调查分析乳酸左氧氟沙星注射液致不良反应/事件(adverse drug reaction / event , ADR/ADE)的发生规律、特点及其影响因素, 促进临床合理用药。方法 采用回顾性和描述性研究方法, 对某院2013年1-6月使用乳酸左氧氟沙沙星注射液的病例798例中发生ADR/ADE患者的性别、用药时间、联合用药情况以及ADR/ADE的具体表现等资料进行分析。结果 798例ADR/ADE总发生率为10.3%(82例), 女性发生率明显高于男性;用药时间越长、使用剂量越大, ADR/ADE发生率越高;消化系统、神经系统ADR/ADE发生率较高。结论 在选用乳酸左氧氟沙星注射液时, 必须慎重考虑不良反应因素。

Objective To investigate the regularity, characteristics and influential factors of ARD/ADE induced by levofloxacin and Sodium Chloride Injectoon, and to promote rational drug use in the clinic. Methods By restrospective and descriptive study, 798 patients having received levofloxacin and sodium chloride injection in this hospital from January to June in 2013 were analyzed retrospectively in terms of gender, medication duration, drug combination, dosage of ADR/ADE. Results Among 798 cases, the incidence of ADR/ADE was 10.3% and the incidence of ADR/ADE among females was higher. The higher the dose was, the higher the incidence was. The incidence of ADR/ADE was high in digestive system and nervous system. Concluslon The ARDS should be under consideration in choice of levofloxacin and sodium chloride injection.