目的 探讨多回波快速自旋回波序列(MEFSE)的T2 mapping定量技术评价左室心肌T2值的价值。方法 30例健康志愿者,均行3.0T心脏磁共振(CMR)Cine电影、T2WI序列、MEFSE T2 mapping序列扫描,依据描述性研究方法,探索MEFSE T2 mapping序列临床应用的可行性和可重复性,测定感兴趣区T2值,应用方差分析方法统计分析心肌17节段和不同供血区下有无差异。应用Bland~Altman分析和Pearson相关分析方法研究此技术在不同观察者间的一致性。结果 健康志愿者17节段心肌T2值不全相等(P＜0.01)。不同冠状动脉供血区T2值无统计学差异(F=1.656,P=0.192)。左室心肌平均T2值如下:基底部,(71.6±7.1)ms;中间部,(77.3±9.2) ms;心尖部,(83.0±8.5)ms,差异有统计学意义(F=14.245,P＜0.01)。根据Bland-Altman一致性分析和Pearson相关分析得到参数测量在观察者间具有良好的一致性,95%一致性界限(-6.1,24.8)ms,相关系数r=0.809。结论 CMR MEFSE T2 mapping定量技术在心脏成像中具有较好的可行性和可重复性。中国健康志愿者中心肌T2值存在节段性差异。
Abstract
Objective To investigate the clinical feasibility and repeatability of a quantitative T2 mapping technique by multi-echo fast spin-echo (MEFSE), and to evaluate the left ventricular myocardial T2 values in different segments. Methods With a 3.0T magnetic resonance (MR) imaging system, according to descriptive research method, cardiovascular magnetic imaging(CMR)was performed in 30 healthy volunteers to investigate the clinical feasibility and repeatability of the quantitative MEFSE T2 mapping technique, combined with Cine and T2WI. T2 values in 17 segments of myocardium and different blood supply areas were measured and compared using one-way ANOVA. The agreement of two radiologists was evaluated by Bland-Altman method and Pearsosn correlation analysis. Results There were differences in the T2 values between some of 17 segmental myocardia (P＜0.01). T2 values were similar in different blood supply areas (F=1.656, P=0.192). Mean myocardial T2 values from the base to the apex were different (F=14.245,P＜0.01): (71.6±7.1) ms (base), (77.3±9.2) ms (middle), (83.0±8.5)ms(apex).According to the Bland—Altman method and Pearson correlation analysis, the measurement of T2 values had a good inter-observer agreement [95% limits of agreement (-6.1,24.8) ms, correlation coefficient r=0.809]. Conclusions Quantitative CMR MEFSE T2mapping technology is feasible and repeatable.Myocardial T2 reference values for the specific CMR setting are provided and they have regional variation.
关键词
心脏磁共振 /
T2 mapping /
健康志愿者
Key words
cardiac magnetic resonance /
T2 mapping /
normal volunteers
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参考文献
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基金
全军后勤科研十二五重大项目(AKJ11J004)
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