目的 评价骨创伤喷雾剂对急慢性软组织疼痛的疗效。方法 急慢性软组织疼痛157例, 随机分为对照组79例和实验组78例。对照组采用盐酸羟考酮口服, 实验组在对照组的基础上加用本院自制的骨创伤喷雾剂喷涂, 比较两组治疗后止痛起效时间、症状改善情况、疼痛VAS评分。结果 治疗后60 min、24 h、7 d实验组VAS评分低于对照组, 差异有统计学意义(P<0.01), 实验组治疗后7 d疼痛、肿胀、局部压痛、遇寒加重缓解程度评分低于对照组, 差异有统计学意义(P<0.05)。实验组有效率(92.39%)高于对照组(80.65%), 差异有统计学意义(P<0.05)。实验组止痛起效时间(9.2±4.5)min短于对照组(42.5±13.1)min, 差异有统计学意义(P<0.05)。结论 骨创伤喷雾剂治疗急慢性损伤疼痛疗效确切, 无明显不良反应。

Objective To evaluate the efficacy and safety of bone trauma spray (containing musk, dragon’s blood, rhubarb, borneol, cinnabar, toads, alcohol and others) on acute and chronic soft tissue pain.Methods From January 2011 to December 2013, 157 out-patients with acute and chronic soft tissue pain were divided into two groups according to the different treatments. 62 patients in the control group used oxycodone hydrochloride orally. 95 patients in the study group used oxycodone hydrochloride orally and bone trauma spray. Analgesia onset time, improvement of symptoms. Before and after treatment, and pain VAS scores were Compared between the two groups. And the safety of drug on patients after treatment was checked.Results Three patients in the study group had local skin allergic reactions, the trial was so put an end. In the study group, VAS pain score was significantly lower than that in the control group(P<0.01). Pain, swelling, local tenderness, aggravation with cold relief after treatment in the study group, compared with the control group, were significantly different(P<0.05). The effective rate in the study group was 92.39%, significantly higher than that (80.65%) in the control group (P<0.05). Analgesia onset time in the study group was significantly shorter than in the control group(P<0.01), and did not find heart, liver, kidney or other organ damages.Conclusions TCM external medicine bone trauma spray for treatment of acute and chronic pain is effective and has no significant side effects.