目的 分析严重烧伤患者检测凝血功能的价值。方法 收集本院严重烧伤84例, 根据年龄分成老年组、中年组和青少儿组;选择健康体检人群25名为健康对照组。观察各组患者在不同时间内各参数的变化情况。结果 老年组入院第1天纤维蛋白原(fibrinogen, FIB)明显升高, 最高达(4.74±1.69)g/L, 与对照组比较差异有统计学意义(P<0.01);凝血酶原时间(prothrombin time , PT)与对照组比较差异无统计学意义;活化部分凝血活酶时间(activated partial thromboplastin time, APTT)和凝血酶时间(thrombin time, TT)在入院第7天升高明显, 达(20.22±6.59)s与对照组比较, 差异有统计学意义(P<0.01)。中年组凝血4项结果 与对照组比较无明显差异, 仅APTT有轻度上升趋势, 但无统计学意义。青少儿组APTT与对照组比较明显升高(P<0.01), 差异有统计学意义(P<0.05);PT与对照组比较偏低, 差异无统计学意义。结论 检测凝血功能对严重烧伤患者的诊治有重要指导价值。

Objective To analyze the changes of coagulation parameters in patients with severe burns at different times. Methods 84 severe burn patients were recruited in this hospital and were divided into three groups according to their different age(The elderly group, middle-aged group, youth group ). At the same time, 25 healthy subjects served as control group. The changes of parameters in all groups of patients at different times were observed. Results FIB in elderly group was significantly higher, up to (4.74±1.69)g/L; it was statistically significant compared with control group(P＜0.01). PT was not statistically significant. APTT and TT increased significantly in the seventh day of admission, up to (20.22±1.69)s, compared with the control group, the difference was statisticallysignificant(P＜0.01). Therewas no significant difference between the coagulation Results of the middle-aged group and the control group. APTT showed a mild upward trend, but there was no statistically significant difference. APTT in youth group and the control group significantly increased, the difference was statistically significant. PT was low, compared with control group(P＜0.01), the difference was not statistically significant(P＜0.05). Conclusion Coagulation detection in clinical diagnosis and treatment is important for patients with severe burns