目的 探讨嗜酸细胞性慢性鼻-鼻窦炎(eosinophilic chronic sinusitis, ECRS)中嗅区黏膜嗜酸性粒细胞(eosinophills, EOS)浸润水平与嗅觉障碍间的关系。方法 选择接受鼻内镜手术治疗的ECRS患者45例,术前行T&T嗅觉检查法嗅觉功能检测,术中取嗅区黏膜活检,HE染色,计数黏膜上皮下EOS,计算Spearman’s Rank 相关系数r。结果 45例ECRS患者嗅觉功能评分为2.3±1.9,嗅区黏膜上皮下EOS计数为(253±102)/HP,Spearman’s Rank 相关系数r=0.68(P<0.01)。结论 ECRS患者嗅觉功能下降与嗅区黏膜EOS浸润存在明显相关性。
Abstract
Objective To study the relationship between olfactory dysfunction and eosinophila in eosinophilic chronic rhinosinusitis. Methods 45 patients with ECRS, 29 males and 16 females, age range 23 to 65 with average 33.7. Olfactory function was evaluated by T&T method, mucosal tissue specimens were collected at the time of surgery and eosinophil counts were used to identify histologic feature. Spearman’s rank correlation was assessed. Results The olfactory dysfunction was observed in ECRS patients with 2.3±1.9 and correlated with eosinophil counts (253±102)/HP with(r=0.68,P<0.01). Conclusions The olfactory dysfunction in ECRS is correlated with eosinophil counts in olfactory nasal mucosa.
关键词
嗜酸细胞性慢性鼻-鼻窦炎 /
鼻黏膜 /
嗅觉障碍 /
嗜酸性粒细胞
Key words
eosinophilic chronic sinusitis /
nasal mucosa /
olfactory dysfunction /
eosinophills
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参考文献
[1] Tokens W J,Lund V J,MuUol J,et al.European Position Paper on Rhinosinusitis and Nasal Polyps [J]. Rhinol Supply,2012,50 (Suppl23):298.
[2] Czerny M S, Namin A, Gratton M A, et al.Histopathological and clinical analysis of chronic rhinosinusitis by subtype[J]. Int Forum Allergy Rhinol,2014,4:463-469.
[3] Hu Y, Cao P P, Liang G T, et al.Diagnostic significance of blood eosinophil count in eosinophilic chronic rhinosinusitis with nasal polyps in Chinese adults[J].Laryngoscope,2012,122: 498-503.
[4] Meltzer E O, Hamilos D L, Hadley J A, et al. Rhnosinusitis: developing guidlance for clinical trials[J]. J Allergy Clin Immunol,2006,118(5 Suppl): 57-61.
[5] Snidvongs K,Chin D,Sacks R, et al.Eosinophilic rhinosinusitis is not a disease of ostiomeatal occlusion[J]. Laryngoscope, 2013,123: 1070-1074.
[6] Ying S, Durham S R, Jacobson M R, et al.Tlymphocytes and mast cells express messenger RNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis[J]. Immunology,1994,82(2): 200-206.
[7] Ghaffar O,Lavigne F,Kmamil A, et al. Interleukin-6 expression in chronic sinusitis: colocalization of gene transcripts to eosinophils, macrophages[J]. T lymphocytes, and mast cells,1998,118(4):504-511.
[8] Soler Z M, Sauer D A, Mace J, et al. Relationship between clinical measures and histopathologic findings in chronic rhinosinusitis[J]. Otolaryngol Head Neck Surg,2009,141(4): 454-461.
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