目的 探讨PPI难治性GERD(Refractory gastroesophageal reflux disease,rGERD)患者的流行病学特征。方法 采用前瞻性队列研究方法,对2013-01至2013-12武警总医院消化内科胃食管反流病专病门诊初步诊断的GERD患者进行临床流行病学调查。根据标准剂量PPI(埃索美拉唑40 mg,1次/早)治疗后4周后的疗效将患者分为rGERD组和对照组。问卷包括一般情况和胃食管反流病问卷,以及反流症状积分表和焦虑、抑郁评价量表。结果 96例中rGERD组46例,占47.9%;对照组50例,占52.1%。两组患者在性别、年龄、体质指数(BMI)、典型症状、吸烟饮酒史间差异无显著性,但rGERD组患者的胃食管反流病问卷(GerdQ)、反流症状积分表(RSS)、焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均显著高于对照组(P＜0.01)。结论 rGERD患者的一般的人口统计学指标无鉴别诊断价值,但GerdQ、反流症状积分、SAS量表、SDS量表评分有助于rGERD的诊断。
Abstract
Objective To study the clinical epidemiologic features of refractory gastroesophageal reflux disease (rGERD). Methods The patients with GERD initially diagnosed by GerdQ≥8 in this GERD clinic from January 2013 to December 2013 were investigated in the prospective cohort study. Questionaires including demography characteristics and GERD questionnaire(GerdQ), reflux symptoms scale(RSS) along with Self-rating Anxiety scale(SAS) and Self-rating Depression Scale(SDS) were used. After 4 weeks-PPI therapy of standard dose ( esomeprazole , 40mg, qd), all patients were divided into PPI-nonresponsive (namely rGERD ) group and PPI- responsive(control) group. All the data were input into database with EpiData 3.0 software and analyzed with SPSS 15.0 software.Results After treatment, 96 outpatients with GERD were divided into rGERD group (46 cases) and control group (50 cases). There was no significant difference in the age, gender, body mass index (BMI, kg/m2), symptoms (P>0.05) between the two groups. However, scores of GerdQ, RSS,SAS and SDS in patients with rGERD group were higher(P＜0.01). Conclusion The demographic indicators have no differential diagnostic value in patients with rGERD, but the GerdQ, RSS,SAS and SDS scores are helpful in the diagnosis of rGERD.
关键词
GERD /
PPI /
量表
Key words
GERD /
PPI /
scale
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参考文献
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