目的 观察热毒宁注射液联合阿奇霉素治疗小儿支原体肺炎的疗效及对炎性介质、免疫功能的影响。方法 将我院2011-2012年收治的104例支原体肺炎患儿按随机数字表分为联合组和对照组,每组52例。对照组采取阿奇霉素序贯治疗,联合组采取热毒宁联合阿奇霉素序贯治疗,两组均以14 d为观察节点。比较两组的疗效和X线消失时间,检测两组CRP、IL-6、免疫球蛋白水平并进行比较。结果 (1) 联合组显效率(88.5%)与对照组(59.6%)比较,差异有统计学意义(χ²=11.260, P＜0.01);(2)联合组X线消失时间为(10.23±1.82)d,短于对照组的(13.35±2.21)d(t=6.022,P＜0.01);(3) 治疗前联合组和对照组比较,炎性介质及免疫功能指标均无统计学差异;治疗后两组比较,CRP、IL-6、IgM、IgG、IgA均有统计学差异(P＜0.01)。结论 热毒宁注射液联合阿奇霉素能够协同控制炎性反应,增强免疫功能,提高临床疗效。

Objective To observe efficacy and influences of Reduning injection combined with azithromycin on inflammatory mediators and immune function in children with mycoplasma pneumonia. Methods 104 children with mycoplasma pneumonia meeting inclusion criteria from 2011 to 2012 in this hospital were randomly divided into 52 cases of study group and control group,52 in each. The control group was given azithromycin sequential therapy,andthe study group was given azithromycin sequential therapy and Reduning injection, both groups were treated for 14 days.Symptoms and signs wereobserved before and after treatment, improvements timewas recorded,CRP,IL-6,immunoglobulin levels were detected,clinical efficacy was evaluated. Results (1)The total effectiverates in study group and control group were 88.5% and 59.6%, respectively,with a significant difference(χ²=11.260,P＜0.01). (2) X line disappearing time of the study group was (10.23±1.82) d, in the control group was (13.35±2.21)d, with significant difference between the two groups (t=6.022, P＜0.01). (3) The inflammatory medium and immune function instudy group and control group were not significantly different before treatment; after treatment, the CRP, IL-6, IgM, IgG, IgA of the two groups were significantly different (all P＜0.01). Conclusions Reduning injection combined with azithromycin can synergistically control the inflammatory response, enhance immune function,andimprove the clinical efficacy.