目的 对比血管性帕金森综合征(vascular Parkinson’s syndrome,VP)与帕金森病(Parkinson’s disease,PD)临床特点及影像学特征。方法 收集我院神经内科收治的70例VP患者作为VP组;同期来我院治疗的70例PD患者为PD组,记录并比较两组现病史(高血压病、冠心病、高脂血症、糖尿病、脑卒中),临床症状(静止性震颤、行走困难、步态不稳、偏侧躯体感觉障碍),以及头颅影像学改变。结果 VP组和PD组高血压病、冠心病、高脂血症、糖尿病、脑卒中发病率分别为(46%、52%、54%、40%、57%)、(30%、27%、28%、22%、38%),差异有统计学意义(P<0.05);PD组以静止性震颤为主,与VP组差异有统计学意义(P<0.05),而VP组以行走困难、步态不稳为主要表现,与PD组比较,差异有统计学意义(P<0.05);VP组老年性脑改变数量、梗死灶数量明显多于PD组,差异有统计学意义(P<0.05)。结论 高血压病、冠心病、高脂血症、糖尿病、脑卒中为VP的危险因素,VP临床症状及影像学改变不同于PD。

Objective To compare vascular Parkinson’s syndrome and Parkinson’s disease characterized by clinical features and imaging.Methods In department of Neurology in this hospital from December 2010 to August 2014 a total of 70 patients with VP were ascribed to VP group; in the same period in this hospital, 70 patients with Parkinson’s disease were ascribed to Parkinson’s disease group (PD group) . (1) We recorded the two groups’ medical history (hypertension, coronary heart disease, high fat cholesterol, diabetes, stroke), clinical manifestations and symptoms (resting tremor, difficulty in walking, unsteady gait, gait panic, lateral somatosensory disorders). (2) The changes in neuroimaging were observed.Results VP group and PD group had hypertension, coronary heart disease, high fat cholesterol, diabetes, stroke (46%、52%、54%、40%、57%,respectively) and (30%、27%、28%、22%、38%,respectively), the difference was statistically significant (P<0.05).The symptoms in Parkinson’s disease group were mainly resting tremor, the difference between PD and VP group was statistically significant (P<0.05); and the main symptoms in VP patients were difficulty in walking and unsteady gait , compared with the Parkinson’s disease group, the difference was statistically significant (P<0.05).In VP group, the number of senile brain changes and cerebral infarction were significantly more in number than in Parkinson’s disease group, the difference was statistically significant (P<0.05). Conclusions Hypertension, coronary heart disease, high fat cholesterol, diabetes, and stroke, are risk factors for vascular Parkinson’s syndrome. The clinical symptoms and imaging changes of VP are different from those of PD.