目的 观察消痰化瘀方对痰阻血瘀型短暂性脑缺血发作(transient ischemic attack,TIA)患者血脂、血流变、血小板聚集率、颅内动脉平均血流速度的干预作用。方法 将符合纳入条件的64例TIA患者为观察对象,并按入院先后顺序奇偶数分组法分为治疗组和对照组各32例。治疗组在对照组西药治疗方案的基础上口服消痰化瘀方。观察两组患者治疗前后血脂、血流变、血小板聚集率、颅内动脉平均血流速度指标变化。结果 血脂:治疗组血清总胆固醇(TC)、低密度脂蛋白(LDL-C)指标较对照组降低显著,高密度脂蛋白(HDL-C)指标较对照组升高显著,差异有统计学意义(P＜0.05);血流变及血小板聚集率:治疗组全血黏度、血浆黏度、纤维蛋白原、血小板聚集率较对照组降低显著,差异有统计学意义(P＜0.05);颅内动脉平均血流速度:治疗组颅内动脉平均血流速度较对照组升高显著,差异有统计学意义 (P＜0.05)。结论 消痰化瘀方能显著降低患者血脂中的TC、LDL-C水平并升高HDL-C水平,能显著改善患者血流变,降低血小板聚集率,提高颅内动脉平均血流速度。

Objective To observe phlegm obstruction and blood stasis on the observation the interventioning effect of Xiaotan Huayu Formula on blood lipids, hemorrheology, platelet aggregation rate, and average blood flow velocity of intracranial artery in patients with transient ischemic attack. Methods 64 patients with TIA meeting the conditions were recruited as observed objects, and according to the order of admission in hospital, and odd even, they were divided into study group and control group, 32 cases each. The two groups of patients’ age, sex, course of the disease, and indicators were observed without statistical significant difference (P>0.05). The study group that was treated on the basis of Western medicine as in the control group receiued Xiaoran Huayn Formula (eliminating phlegm and removing blood stasis). We observed two groups of patients, before and after treatment, blood lipids, hemorrheology, platelet aggregation rate,average intracranial artery blood flow velocity index changes. Results For blood fats, in the study group, serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) index was reduced significantly, high density lipoprotein cholesterol (HDL-C) indicators were higher than in the control group, the difference was statistically significant (P<0.05). For hemorrheology and platelet aggregation rate, in the study group, whole blood viscosity, plasma viscosity, fibrinogen, platelet aggregation rate decreased significantly than in the control group, the difference was statistically significant (P<0.05). In terms of average intracranial artery blood flow velocity, in the treatment group, average of intracranial artery blood flow velocity (Vm) was higher than in the control group, the difference was statistically significant (P<0.05). Conclusions Xiaotan Huayu Formula can significantly reduce the patients’ blood fat of TC, LDL-C level and increase HDL-C level, can significantly improve patient’s hemorrheology, decrease the rate of platelet aggregation, make higher average blood flow velocity of intracranial arteries.