目的 比较肠道四种准备方法的清洁有效度、不良反应发生情况及耐受性。方法 选取320例拟行结肠镜检查的患者,随机分成4组,采用单盲、前瞻性、对照研究。A组复方聚乙二醇电解质散(polyethylene glycol electrolyte powder,PEG)4 L分次口服,B组PEG 2 L+酚酞片口服,C组服用PEG 2 L,D组服用硫酸镁+酚酞片。比较4组患者肠道清洁程度、不良反应发生情况及耐受性。结果 A组、B组肠道清洁效果较理想,清洁有效率分别为90.0％、88.8％,优于C、D两组的73.8％、67.5％(P<0.05);D组不良反应总发生率为42.5％,A、B、C组分别21.3％、25.0％、27.6％,D组明显高于A、B、C组(P<0.05);D组耐受性为75.0%,也明显低于A、B、C组的95％、92.5％、87.5％(P<0.05)。结论 PEG 4 L分次口服,以及低剂量PEG联合其他有协同作用的泻药,安全有效,耐受性也较好,可提供较理想的肠道清洁效果。
Abstract
Objective To compare the quality of cleansing, adverse events, and patient tolerability of four different methods of colon cleansing in preparation for colonoscopy. Methods Three hundred and twenty patients undergoing colonoscopy were randomized into four groups in a prospective, single-blind, controlled trial. Group A received 4 litres of compound polyethylene glycol electrolyte powder (PEG). Group B received 2 litres of PEG plus oral phenolphthalein tablets. Group C received 2 litres of PEG, patients in group D received magnesium sulfate plus phenolphthalein tablets. The quality of cleansing, adverse events and patient tolerability were compared between the four groups. Results Group A and B (90.0%, 88.8%, respectively) showed a significantly greater quality of colon cleansing, compared with groups C and D (73.8%, 67.5%, respectively) (P<0.05). The incidence of adverse events in Group D (42.5%) was significantly higher, compared with group A, B, and C (21.3%, 25.0%, 27.6%, respectively) (P<0.05). A significantly lower tolerability was also observed in group D (75.0%), compared with group A, B, and C (95.0%, 92.5%, 87.5%, respectively) (P<0.05). Conclusions Four litres of PEG and low –volume PEG plus other synergistic laxatives are safe, effective and well tolerated by patients for colon cleansing, and can provide better colon cleansing quality.
关键词
肠道准备 /
结肠镜 /
复方聚乙二醇 /
硫酸镁 /
酚酞
Key words
bowel preparation /
colonoscopy /
pdyethylene glycol electrolyte powder /
magnesium sulfate /
phenolphthalein
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