目的 探讨神经外科手术患者系统规范化护理模式对应激反应的影响。方法 2012-03至2014-11期间我院进行的脑神经胶质瘤手术患者70例，随机分为实验组和对照组。对照组给予常规护理，实验组除接受常规护理外还进行系统规范化的护理干预，比较分析两组患者围手术期的应激反应。结果 实验组患者在手术前一天(T₁)血压和心率为[(125.43±19.32)mmHg、(78.98±10.94)次/分]、进入手术室后插气管时(T₂)血压和心率为[(128.45±18.35)mmHg、(78.94±11.47)次/min]、手术结束时(T₃)血压和心率为[(120.15±16.12)mmHg、(83.45±15.15)次/min]手术后的24 h(T₄)血压和心率为[(120.35±17.90)mmHg，(72.25±12.63)次/min]和手术后72 h(T₅)血压和心率为[(121.12±15.23)mmHg、(70.35±12.95)次/min]，这几个时刻的心率和收缩压均明显低于对照组，差异有统计学意义(P<0.05)。实验组患者血清IL-6在手术前后的波动较对照组小，差异有统计学意义(P<0.05)，术后实验组患者血清皮质醇含量变化较对照组小，差异有统计学意义(P<0.05)，术后72 h对照组较实验组更焦虑(P<0.05)。结论 系统规范化护理模式可以调节患者手术中的应激反应，维持患者内环境的稳定，对患者的手术效果和术后康复有着重要的促进作用。

Objective To study the effect of system standardized mursing mode on operation stress reaction in patients undergoing neurosurgery. Methods The clinical data of 35 glioma surgery patients from May 2007 to June 2009 who were treated with routine care as the control group, and of other 35 glioma surgery patients from March 2012 to November 2014 who were treated with routine care and system standardized nursing mode care as the study group were retrospectively analyzed. The perioperative stress response between the two groups was compared. Results The heart rate and systolic blood pressure of the patients in the study group were much lower than in the control group(P<0.05). The fluctuations of serum IL-6 and cortisol in the study group were smaller than in the control group(P<0.05). The scores of anxiety value in the 72 h were much higher in the control group(P<0.05). Conclusions Standardized nursing model can be used in adjusting patients’ surgical stress response, it can maintain a stable environment, improve the efficacy of surgery and plays an important role in rehabilitation after surgery.