目的 观察武警某部男性青年官兵幽门螺杆菌(H.pylori, Hp)在上消化道疾病中的感染及耐药情况,指导临床用药。方法 选取2014-06至2015-03间因上消化道疾病在我院内镜室检查的172例青年官兵为研究对象,均经胃镜检查并钳取胃黏膜标本,经Hp培养、分离,采用KB法检测Hp菌株对克拉霉素、甲硝唑、左氧氟沙星、阿莫西林、四环素、呋喃唑酮等抗生素的耐药率。结果 172例标本共84例Hp培养阳性,阳性率为48.8%,32例慢性浅表性胃炎Hp阳性15例,8例慢性非萎缩性胃炎Hp阳性4例,26例糜烂性胃炎Hp阳性12例;41例胃溃疡Hp阳性20例,35例十二指肠溃疡Hp阳性18例,30例复合性溃疡Hp阳性15例。经比较发现,各疾病种类的Hp阳性率差异无统计学意义。84例Hp阳性标本对常用抗生素的耐药率分别为:克拉霉素(31.0%)、甲硝唑(35.7%)、左氧氟沙星(11.9%)、阿莫西林(1.2%)、四环素(1.2%)、呋喃唑酮(0)。结论 青年官兵Hp感染率较高,对阿莫西林、四环素、呋喃唑酮的耐药率低,推荐在Hp根除治疗中首选使用。

Objective To observe the Helicobacter pylori (Hp) infection in the upper gastrointestinal tract and its antibiotic resistance in young males of Armed Police Forces in order to facilitate medication .Methods A total of 172 young males of Armed Police Forces with upper gastrointestinal tract diseases were selected between June 2014 and March 2015. Gastric mucosa was clamped via gastroscopes and Hp was cultivated and selected. The KB test was performed to test the susceptibility of clarithromycin, metronidazole, levofloxacin, amoxicillin, tetracycline and furazolidone to Hp. Results 84 strains of Hp were isolated from the gastric mucosa of the 172 cases, and the positive incidence was 48.8%. Hp positiveness was found among 15 of the 32 chronic superficial gastritis patients, , 4 of the 8 chronic non-atrophic gastritis patients, 12 of the 26 erosive gastritis patients, 20 of the 41 gastric ulcer patients, 18 of the 35 cases of duodenal ulcer and among15 of the 18 cases of gastric combined duodenal ulcer. No significant difference was found in the detection rate of Hp between patients with chronic superficial gastritis, chronic non-atrophic gastritis, erosive gastritis, gastric ulcer or duodenal ulcer. The drug susceptibility test indicated that the drug-resistance rate of 84 Hp strains to clarithromycin, metronidazole, levofloxacin, amoxicillin, tetracycline and furazolidone was 31.0%, 35.7%, 11.9%, 1.2%, 1.2%, and 0 respectively. Conclusion Hp has a high infection rate in young males of Armed Police Forces. The drug-resistance to amoxicillin, tetracycline and furazolidone is low, so these drugs should be recommended for use in Hp eradication therapy.