Krüppel样因子4与免疫细胞调控

孙亮,李鑫,姬文婕,魏路清,综述,张健鹏,审校

武警医学 ›› 2016, Vol. 27 ›› Issue (2) : 189-192.

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PDF(842 KB)
武警医学 ›› 2016, Vol. 27 ›› Issue (2) : 189-192.
综述

Krüppel样因子4与免疫细胞调控

  • 孙亮1,2,李鑫2,姬文婕2,魏路清2,综述,张健鹏3,审校
作者信息 +
文章历史 +

摘要

炎性反应一旦启动,与炎症有关的细胞因子往往呈瀑布式表达,但这些细胞因子的表达并非是无序和随意的,而是受复杂的网络调控的。但细胞因子在时向上的反常表达及分泌不平衡, 可在局部及全身炎性反应的发生、发展中起决定作用。因此,调控细胞因子的表达方向就成为调控炎性反应发生、发展的重要基础。研究发现,在炎性反应发生、发展过程中,许多转录因子可调控细胞因子的表达,在众多的转录因子中,Krüppel样因子家族是目前的研究热点之一。因此,笔者重点对Krüppel样因子 4(KLF4)对细胞因子表达调控的研究进展进行综述。

关键词

Krüppel样因子4 / 细胞因子 / 调控

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孙亮,李鑫,姬文婕,魏路清,综述,张健鹏,审校. Krüppel样因子4与免疫细胞调控[J]. 武警医学. 2016, 27(2): 189-192

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基金

国家自然科学基金 (81441101) ,武警后勤学院基础研究项目(WHJ2015020)

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