心肌干细胞与心肌梗死区微环境的研究进展

李小雪,综述,孙雷,审校

武警医学 ›› 2016, Vol. 27 ›› Issue (2) : 197-200.

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PDF(882 KB)
武警医学 ›› 2016, Vol. 27 ›› Issue (2) : 197-200.
综述

心肌干细胞与心肌梗死区微环境的研究进展

  • 李小雪,综述,孙雷,审校
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摘要

目前治疗急性心肌梗死(acute myocardial infarction, AMI)的方法主要有药物治疗、冠状动脉旁路移植术(coronary artery bypass grafting, GABG)、经皮冠状动脉旁路介入术(percutaneous coronary intervention, PCI)等。这些方法能通过恢复灌流来缓解患者症状,挽救部分缺血心肌,防止梗死创面的扩大,但对已经形成的纤维瘢痕无能为力,即不能从根本上使已经坏死的心肌修复,改善心肌的舒缩功能。近几年来,研究者们一直在探索解决这一问题的途径,而干细胞技术的兴起和不断发展,无疑给心血管病患者带来了光明和希望。20世纪末以来,大量研究发现,在成体的心肌组织和骨髓中存在具有特异性心肌分化潜能的多能干细胞,即心肌干细胞(cardiac stem cells, CSCs)。心肌梗死后,局部组织缺血缺氧,微环境发生改变,CSCs在多种细胞因子、细胞基质或炎性介质等的作用下被动员至心肌缺血区,向心肌细胞及内皮细胞等分化并表达心肌特异性的蛋白。笔者就CSCs和微环境的研究进展进行综述。

关键词

急性心肌梗死 / 心肌干细胞 / 经皮冠状动脉旁路介入术

引用本文

导出引用
李小雪,综述,孙雷,审校. 心肌干细胞与心肌梗死区微环境的研究进展[J]. 武警医学. 2016, 27(2): 197-200
中图分类号: R542   

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