目的 评价血清骨胶素(cytokeratin 19 fragment,CY21-1)、糖类抗原72-4(cancer antigen 72-4,CA72-4)、神经元特异烯醇化酶(neuron specific enolase,NSE)、鳞状上皮细胞癌抗原(squamous cell carcinoma antigen,SCC)、糖类抗原125(cancer antigen 125,CAl25)、癌胚抗原(carcino embryonic antigen,CEA)等6种血清肿瘤标志物(tumor marker,TM)对肺癌辅助诊断的价值。方法 采用电化学免疫发光方法,检测245例肺癌患者和138例健康体检人群血清中CY21-1、CA72-4、NSE、SCC、CEA、CAl25的水平。结果 肺癌组的各项血清肿瘤标志物水平较健康组均有统计学差异(P<0.05);当特异度为95%时,CY21-1对鳞癌的诊断灵敏度达78.87%,NSE对小细胞癌的灵敏度达91.18%,CEA对腺癌的灵敏度达70.75%;6种癌标联合检测分别对小细胞癌、鳞癌、腺癌的诊断灵敏度达到95.59%、91.55%、86.79%。结论 NSE、CY21-1、CEA分别对小细胞癌、鳞癌、腺癌的诊断价值较高,且多项TM相互联合检测能增加肺癌的诊断灵敏度。
Abstract
Objective To evaluate the value of serum collagen peptide (CY21-1), carbohydrate antigen 72-4 (CA72-4), neuron specific enolase (NSE), squamous epithelial cell carcinoma antigen (SCC), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA),such six kinds of serum tumor markers(TM) in auxiliary diagnosis of lung cancer.Methods With electrochemical immunoassay assay,serum levels of CY21-1,NSE,SCC,CEA,CA72-4 and CAl25 were detected in 245 patients with lung cancer and 138 healthy people.Results The levels of serum tumor markers in lung cancer group were statistically significantly different from those in healthy group (P<0.05). When the specificity was 95%, the diagnostic sensitivity of CY21-1 for squamous cell carcinoma was 78.87%,that of CEA for diagnosis of adenocarcinoma was 70.75%, that of NSE for diagnosis of small cells carcinoma was 91.18%.The diagnostic sensitivity of 6 kinds of tumor markers combined detection of squamous cell carcinoma, adenocarcinoma and small cell carcinoma were 91.55%, 86.79% and 95.59%, respectively.Conclusions The diagnostic value of NSE,CY21-1 and CEA are high in small cell carcinoma,squamous cell carcinoma and adenocarcinoma. Combined detection of multiple tumor markers can improve the sensitivity of diagnosis of lung cancer.
关键词
肿瘤标志物 /
肺癌 /
联合检测 /
诊断灵敏度
Key words
tumor markers /
lung cancer /
combined detection /
diagnostic sensitivity
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参考文献
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