目的 探讨脉冲电磁场(pulsed electromagnetic fields，PEMFs)结合自体红骨髓移植治疗骨缺损的疗效。方法 将四肢新鲜骨折患者随机分为3组，对照组手术过程中植入同种异体骨后行内固定，2 Hz、15 Hz治疗组植入同种异体骨与自体红骨髓复合体后内固定，术后分别配合2 Hz、15 Hz脉冲电磁场治疗;3组患者分别于术后4、12、24、40周复查X线片并进行疗效评定。结果 30例患者治疗后均获得随访，对照组、2 Hz、15 Hz治疗组治愈率分别为80%、100%、90%;在相同时间点上，治疗组骨痂生长情况明显优于对照组(P<0.05);2 Hz治疗组骨痂生成较15 Hz治疗组明显增多(P<0.05);3种治疗方式下肢体的功能恢复情况差异无统计学意义(P>0.05)。结论 联合运用脉冲电磁场、自体红骨髓复合同种异体骨移植能明显促进骨痂生长，修复骨缺损有显著效果。

Objective To study clinical effects of the pulsed electromagnetic fields(PEMFs) combined with autologous red marrow implantation in the treatment of traumatic bone defect.Methods Patients with fresh fractures of the limbs were divided into three groups randomly. The allograft cancellous bone was implanted into the bone defect region before routine fixation in the control group. For 2 Hz and 15 Hz study groups, internal fixation was carried out after the blended autologous red marrow and allograft cancellous bone were implanted, then treated with PEMFs of 2 Hz, 15 Hz. X-ray examination was performed at 4,12,24,40 weeks after fixation in all patients and the effects were evaluated.Results All the 30 patients were followed up after treatment, the cure rates in control group, 2 Hz, 15 Hz study groups were 80%, 100%, 90%, respectively. The formation of bony callus in the study groups were significantly higher than that in the control group at the same time point (P<0. 05), and the formation of bony callus in PEMFs group of 2 Hz was higher than those in the group of 15 Hz (P<0. 05). The functional recovery of upper and lower limbs had no significant difference between the three groups (P<0.05).Conclusions PEMFs combined with the composite of allograft cancellous bone and autologous red marrow can promote the growth of bony callus significantly, and is effective to repair bone defects.