目的 调查影响颈动脉狭窄患者认知功能的因素，为早期识别认知功能损害提供参考。方法 选择经全脑血管数字减影血管造影(DSA)技术诊断的颈动脉狭窄患者116例，通过蒙特利尔认知评估量表(MoCA)评估其认知功能，利用多重线性回归分析筛选认知功能的影响因素。结果 MoCA总分平均为19.23±2.52，检出认知功能损害患者72例，检出率为62.1%;多元线性回归分析结果显示年龄(β=-3.71，P=0.02)、吸烟(β=-2.02，P=0.02)、高血压(β=-2.40，P=0.02)、高血脂(β=-2.65，P=0.02)、糖尿病(β=-3.29，P=0.03)、狭窄程度(β=-4.41，P=0.03)等为颈动脉狭窄患者认知功能的影响因素。结论 颈动脉狭窄患者认知功能的影响因素可能包括血管性危险因素及狭窄本身的病理特征因素。
Abstract
Objective To investigate the factors of cognitive function in patients with carotid artery stenosis and proovide reference for the early identification of cognitive impairment.Methods Clinical data of 116 patients with carotid artery stenosis diagnosed by digital subtraction angiography (DSA) were recruited. The cognitive function was assessed by the Montreal Cognitive Assessment Scale (MoCA). Multivariate analysis was used to screen the influencing factors of cognitive function.Results The mean of total score of MoCA was 19.23±2.52. A total of 72 cases were detected to have cognitive impairment, with a detection rate of 62.1%. Multivariate analysis showed that age (β=-3.71,P=0.02), smoking (β=-2.02,P=0.02), hypertension(β=-2.40,P=0.02), hyperlipemia(β=-2.65,P=0.02), diabetes(β=-3.29,P=0.03) and stenosis degree(β=-4.41,P=0.03) were the influencing factors of cognitive function in patients with carotid stenosis.Conclusions Influencing factors of cognitive function in patients with carotid stenosis may include vascular risk factors and pathological characteristics of stenosis.
关键词
颈动脉狭窄 /
认知功能 /
因素
Key words
carotid artery stenosis /
cognitive function /
factor
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