[1] American Academy of Sleep Medicine. International Classification of Sleep Disorders[M]. 3rd ed. Darien,Illinois, America:American Academy of Sleep Medicine, 2014: 143-161. [2] 中华医学会神经病学分会.中国发作性睡病诊断与治疗指南[J].中华神经科杂志, 2015, 48(6): 445-452. [3] Han F, Lin L, Warby S C, et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China[J]. Ann Neurol, 2011, 70(3): 410-417. [4] Wu H, Zhuang J, Stone W S, et al. Symptoms and occurrences of narcolepsy: a retrospective study of 162 patients during a 10-year period in Eastern China[J]. Sleep Med, 2014, 15(6): 607-613. [5] Wijnans L, Lecomte C, de Vries C, et al. The incidence of narcolepsy in Europe: before, during, and after the influenza A (H1N1) pdm09 pandemic and vaccination campaigns[J].Vaccine, 2013, 31(8): 1246-1254. [6] Winstone A M, Stellitano L, Verity C, et al. Clinical features of narcolepsy in children vaccinated with AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine in England[J]. Dev Med Child Neurol, 2014, 56(11): 1117-1123. [7] Feltelius N, Persson I, Ahlqvist-Rastad J, et al. A coordinated cross-disciplinary research initiative to address an increased incidence of narcolepsy following the 2009-2010 Pandemrix vaccination programme in Sweden[J]. J Intern Med, 2015, 278(4): 335-353. [8] Saariaho A H, Vuorela A, Freitag T L, et al. Autoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus[J]. J Autoimmun, 2015, 63: 68-75. [9] Partinen M, Kornum B R, Plazzi G, et al. Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination[J]. Lancet Neurol, 2014, 13(6): 600-613. [10] Singh A K, Mahlios J, Mignot E. Genetic association, seasonal infections and autoimmune basis of narcolepsy[J]. J Autoimmun, 2013, 43: 26-31. [11] Black S W, Kilduff T S. H1N1 infection of sleep/wake regions results in narcolepsy-like symptoms[J]. Proc Natl Acad Sci U S A, 2016,113(3): 476-477. [12] 董霄松, 李玉茜, 李 静,等. 脑脊液下丘脑分泌素水平测定对中国发作性睡病患者的诊断价值[J]. 中华医学杂志, 2013, 93(26): 2038-2042. [13] Han F, Lin L, Schormair B, et al. HLA DQB1* 06: 02 negative narcolepsy with hypocretin/orexin deficiency[J]. Sleep, 2014, 37(10): 1601-1608. [14] Hallmayer J, Faraco J, Lin L, et al. Narcolepsy is strongly associated with the T-cell receptor alpha locus[J]. Nat Genet, 2009, 41(6): 708-711. [15] Ahmed S S, Schur P H, MacDonald N E, et al. Narcolepsy, 2009 A (H1N1) pandemic influenza, and pandemic influenza vaccinations: what is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants[J]. J Autoimmun, 2014, 50: 1-11. [16] Aran A, Einen M, Lin L, et al. Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children[J]. Sleep, 2010, 33(11): 1457-1464. [17] Kawashima M, Lin L, Tanaka S, et al. Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy[J]. Sleep, 2010, 33(7): 869-874. [18] Kim T W, Kim H J, Kang D W, et al. Four narcolepsy cases after H1N1 infection or vaccination[J]. Sleep Med Res, 2015, 6(1): 38-41. [19] Leschziner G. Narcolepsy: a clinical review[J]. Pract Neurol, 2014, 14(5): 323-331. [20] Boscolo-Berto R, Viel G, Montagnese S, et al. Narcolepsy and effectiveness of gamma-hydroxybutyrate (GHB): a systematic review and meta-analysis of randomized controlled trials[J]. Sleep Med Rev, 2012, 16(5): 431-443. [21] Li J, Hu Z, Lecea L. The hypocretins/orexins: integrators of multiple physiological functions[J]. Br J Pharmacol, 2014, 171(2): 332-350. [22] Shukla C, Basheer R. Metabolic signals in sleep regulation: recent insights[J]. Nat Sci Sleep, 2016, 8: 9-20. [23] Diniz Behn C G, Klerman E B, Mochizuki T, et al. Abnormal sleep/wake dynamics in orexin knockout mice[J]. Sleep, 2010, 33(3): 297-306. [24] Saper C B, Fuller P M, Pedersen N P, et al. Sleep state switching[J]. Neuron, 2010, 68(6): 1023-1042. [25] Takahashi K, Lin J S, Sakai K. Neuronal activity of orexin and non-orexin waking-active neurons during wake-sleep states in the mouse[J]. Neuroscience, 2008, 153(3): 860-870. [26] Wang J, Greenberg H. Status cataplecticus precipitated by abrupt withdrawal of venlafaxine[J]. J Clin Sleep Med, 2013, 9(7): 715. [27] Lu J, Sherman D, Devor M, et al. A putative flip-flop switch for control of REM sleep[J]. Nature, 2006, 441(7093): 589-594. [28] Brown R E, Basheer R, McKenna J T, et al. Control of sleep and wakefulness[J]. Physiol Rev, 2012, 92(3): 1087-1187. [29] John J, Thannickal T C, McGregor R, et al. Greatly increased numbers of histamine cells in human narcolepsy with cataplexy[J]. Ann Neurol, 2013, 74(6): 786-793. [30] Overeem S, Reijntjes R, Huyser W, et al. Corticospinal excitability during laughter: implications for cataplexy and the comparison with REM sleep atonia[J]. J Sleep Res, 2004, 13(3): 257-264. [31] Khatami R, Birkmann S, Bassetti C L. Amygdala dysfunction in narcolepsy-cataplexy[J]. J Sleep Res, 2007, 16(2): 226-229. [32] Fung S J, Xi M, Zhang J, et al. Projection neurons from the central nucleus of the amygdala to the nucleus pontis oralis[J]. J Neurosci Res, 2011, 89(3): 429-436. [33] Xi M, Fung S J, Sampogna S, et al. Excitatory projections from the amygdala to neurons in the nucleus pontis oralis in the rat: an intracellular study[J]. Neuroscience, 2011, 197: 181-190. [34] Oishi Y, Williams R H, Agostinelli L, et al. Role of the medial prefrontal cortex in cataplexy[J]. J Neurosci, 2013, 33(23): 9743-9751. [35] Burgess C R, Oishi Y, Mochizuki T, et al. Amygdala lesions reduce cataplexy in orexin knock-out mice[J]. J Neurosci, 2013, 33(23): 9734-9742. [36] Liu M, Blanco-Centurion C, Konadhode R R, et al. Orexin gene transfer into the amygdala suppresses both spontaneous and emotion-induced cataplexy in orexin knockout mice[J]. Eur J Neurosci, 2016, 43(5):681-688. [37] Zhang J, Li B, Yu L, et al. A role for orexin in central vestibular motor control[J]. Neuron, 2011, 69(4): 793-804. [38] Mochizuki T, Arrigoni E, Marcus J N, et al. Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice[J]. Proc Natl Acad Sci U S A, 2011, 108(11): 4471-4476.